Author + information
- August M. Watanabe, MD, FACC*
- ↵*Address for reprints: August M. Watanabe, MD, Indiana University School of Medicine, 1100 West Michigan Street, Indianapolis, Indiana 46223.
The properties of beta-adrenergic receptors in the cardiovascular system have been studied in the past by two experimental approaches, which can be termed pharmacologic and biochemical. In the pharmacologic approach, the nature of a drug interaction with receptors is deduced from alterations in the physiologic properties of the tissue caused by administration of various concentrations of the drug. Many important concepts about beta-adrenergic receptors have come from such indirect pharmacologic studies. The biochemical approach directly assesses the interaction of drugs with beta-adrenergic receptors by studying the binding of radiolabeled antagonists and agonists with the receptor. This relatively new approach has provided a large amount of new information regarding the intrinsic properties of beta-adrenergic receptors and modification of these properties by physiologic stresses, administration of drugs and disease states. The biochemical approach has also been applied recently to the study of beta-adrenergic receptors in human beings. In the future, substantial clinically relevant new information regarding the nature of beta-adrenergic receptors in physiologic and pathologic conditions should result from application of a combination of the biochemical and physiologic approaches to studies in human beings.
The author's research cited in this paper was supported by the Herman C. Krannert Fund, Indianapolis, Indiana, by grants HL18795, HL06308, HL07182 from the National Heart, Lung, and Blood Institute; National Institutes of Health, Bethesda, Maryland, and by the American Heart Association, Indiana Affiliate, Indianapolis, Indiana.
- American College of Cardiology Foundation