Author + information
- Received July 20, 1982
- Revision received October 15, 1982
- Accepted October 25, 1982
- Published online March 1, 1983.
- Roy Jedeikin, MD*,
- Paul C. Gillette, MD, FACC1,
- Arthur Garson Jr., MD, FACC,
- Co-Burn J. Porter, MD,
- Stanley Beder, MD,
- Peter Baron, MD and
- Alexander J. Zinner III
- ↵1Address for reprints: Paul C. Gillette, MD, Pediatric Cardiology, Texas Children's Hospital, 6621 Fannin, Houston, Texas 77030.
The anterograde effective refractory period of the accessory connection was determined before and after the administration of ouabain (0.015 mg/kg intravenously) during electrophysiologic studies in 21 patients with Wolff-Parkinson-White syndrome. The mean age (± standard deviation) was 10 ± 2 years (range 1 month to 31 years). Each patient had stopped taking all cardiac drugs for more than 36 hours. Determination of the anterograde effective refractory period of the accessory connection was made using the atrial extrastimulus technique. A change in the anterograde refractory period of the accessory connection was defined as an increase or decrease of greater than 10 ms from the value before ouabain administration. The post-ouabain anterograde effective refractory period of the accessory connection increased in 2 (9%) of the 21 patients, decreased in 9 (43%) and was unchanged in 10 (48%). This study demonstrated a decrease in the anterograde effective refractory period of the accessory connection of 43% of patients with Wolff-Parkinson-White syndrome after the administration of ouabain.
↵a Present address: Department of Pediatrics, Box 386, University of Virginia, Charlottesville, Virginia 22908.
This study was suppoiled in part by four grants from the National Institutes of Health, Bethesda, Maryland: General Clinic Research Branch Grant RR-00188, United States Public Health Service Grant HL-07190, Research Career Devdopmeht Award HL-0057l, and Young Investigator's Award HL-24916 and by the Christopher Relyea Fund. Houston, Texas
- Received July 20, 1982.
- Revision received October 15, 1982.
- Accepted October 25, 1982.
- American College of Cardiology Foundation