Author + information
- Received July 29, 1982
- Revision received December 13, 1982
- Accepted January 2, 1983
- Published online June 1, 1983.
- Geoffrey S. Hirsowitz, MD,
- Jeffrey B. Lakier, MD, FACC*,
- Daniel S. Marks, MD,
- Tennyson G. Lee, MD, FACC,
- A. David Goldberg, MD, FACC and
- Sidney Goldstein, MD, FACC
- ↵*Address for reprints: Jeffrey B. Lakier, MD, Henry Ford Hospital, Division of Cardiovascular Medicine, 2799 West Grand Boulevard, Detroit, Michigan 48202.
A comparison was made of the estimated size of the myocardial infarction occurring in 26 patients with a first infarction using creatine kinase (CK) enzyme release between radionuclide gated blood pool measurement of total and regional ventricular function and thallium-201 scintigraphic measurement of myocardial perfusion defects. Creatine kinase estimates of infarct size (enzymatic infarct size) correlated closely with the percent of abnormal contracting regions, left ventricular ejection fraction and thallium-201 estimates of percent of abnormal perfusion area (r = 0.78, 0.69 and 0.74, respectively, p < 0.01). A close correlation also existed between percent abnormal perfusion area and percent of abnormal contracting regions (r = 0.81, p < 0.01) and left ventricular ejection fraction (r = 0.69, p < 0.01). Enzymatic infarct size was larger in anterior (116 ± 37 CK-g-Eq) than inferior (52 ± 29 CK-g-Eq) myocardial infarction (p < 0.01) and was associated with significantly more left ventricular functional impairment as determined by left ventricular ejection fraction (33 ± 7 versus 60 ± 10%) (p < 0.01) and percent abnormal perfusion area (58 ± 14 versus 13 ± 12) (p < 0.01). No significant correlation was observed between enzymatic infarct size and right ventricular ejection fraction. These different methods of estimating infarct size correlated closely with each other in these patients with a first uncomplicated myocardial infarction.
- Received July 29, 1982.
- Revision received December 13, 1982.
- Accepted January 2, 1983.
- American College of Cardiology Foundation