Author + information
- Received September 28, 1986
- Revision received March 25, 1987
- Accepted April 20, 1987
- Published online September 1, 1987.
- Martin E. Goldman, MD, FACC*,1,
- Francisco Mora, MD†,
- Theresa Guarino, RN†,
- Valentin Fuster, MD, FACC* and
- Bruce P. Mindich, MD, FACC†
- ↵1Address for reprints: Martin Goldman, MD, Division of Cardiology, Mount Sinai Hospital, One Gustave L. Levy Place, New York, New York 10029.
To investigate the mechanism and time of onset of ventricular dysfunction after mitral valve replacement, 18 patients with pure, severe mitral regurgitation (of whom 10 underwent mitral valve repair and 8 standard mitral valve replacement with papillary muscle excision) were studied by intraoperative two-dimensional echocardiography immediately before and immediately after the operative procedure. No patient sustained a perioperative myocardial infarction or had any residual mitral regurgitation.
Although preoperative hemodynamics were similar, postoperatively the patients with valve repair had a lower pulmonary capillary wedge pressure than did the patients with valve replacement (8.6 ± 1.9 versus 14.4 ± 7.5 mm Hg, p < 0.04). Although intraoperative echo-cardiographic ejection fraction fell significantly after mitral valve replacement (0.64 ± 0.11 to 0.40 ± 0.09, p < 0.0001), it was maintained after valve repair (0.44 ± 0.20 to 0.49 ± 0.16, p = NS). Additionally, regional myocardial contractile abnormalities in the anterior and posterior septum were detected immediately after the procedure by intraoperative echocardiography in the patients with valve replacement, but not in those with repair. These postoperative regional contractile abnormalities after papillary muscle resection have not been described previously. Resection of the papillary muscles may disrupt the muscle bundle alignment and induce contractile abnormalities remote from the excised muscle. This study demonstrated that significant global and regional ventricular dysfunction develops immediately after removal of the papillary muscles, whereas myocardial contractility is preserved in patients undergoing mitral valve repair. Therefore, with intraoperative echocardiography to assure minimal residual regurgitation, surgeons should attempt to preserve ventricular function by performing mitral valve reconstruction in patients with mitral regurgitation.
- Received September 28, 1986.
- Revision received March 25, 1987.
- Accepted April 20, 1987.
- American College of Cardiology Foundation