Author + information
- Received February 29, 1988
- Revision received June 8, 1988
- Accepted June 17, 1988
- Published online November 1, 1988.
- David R Holmes, MD, FACC∗,a,b,c,d,e,f,g,h,
- Richard Holubkov, MSa,b,c,d,e,f,g,h,
- Ronald E Vlietstra, MBChB, FACCa,b,c,d,e,f,g,h,
- Sheryl F Kelsey, PhDa,b,c,d,e,f,g,h,
- Guy S Reeder, MD, FACCa,b,c,d,e,f,g,h,
- Gerald Dorros, MD, FACCa,b,c,d,e,f,g,h,
- David O Williams, MD, FACCa,b,c,d,e,f,g,h,
- Michael J Cowley, MDa,b,c,d,e,f,g,h,
- David P Faxon, MD, FACCa,b,c,d,e,f,g,h,
- Kenneth M Kent, MD, FACCa,b,c,d,e,f,g,h,
- Lamberto G Bentivoglio, MD, FACCa,b,c,d,e,f,g,h,
- Katherine Detre, MD, DrPHa,b,c,d,e,f,g,h,
- The Co-Investigators of the National Heart, Lung, Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry∗,a,b,c,d,e,f,g,h
- ↵∗Address for reprints: David R. Holmes, Jr., MD, Mayo Clinic, 200 Street Southwest, Rochester, Minnesota 55905.
Because the effects of changing technology in percutaneous transluminal coronary angioplasty, increased operator experience and use of the procedure in patients with extensive disease are unknown in regard to complication patterns, the initial 1977–1981 cohort and the recent 1985–1986 cohort of the National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry were analyzed with respect to complications. Compared with the initial cohort of 1.155 patients, the 1,801 new cohort patients were older and had an increased prevalence of multivessel coronary artery disease, depressed left ventricular function and prior infarction.
Overall complication rates in the recent cohort were either unchanged or decreased from the rates in the initial cohort despite a higher risk patient population. The most significant decreases were in the incidence of coronary spasm (p < 0.001, and the need for emergency coronary bypass surgery (p < 0.01). Overall in-hospital mortality was low but was dependent on the extent of vessel disease—0.2% for single vessel disease, 0.9% for double vessel disease and 2.2% for triple vessel disease (p < 0.001 for linear trend). Acute coronary complications of branch occlusion, dissection or abrupt closure were associated with increased rates of death, nonfatal infarction or need for emergency surgery. Factors showing a multivariate association with increased mortality included a history of congestive heart failure (p < 0.001), age ≥65 years (p < 0.01), triple vessel or left main coronary artery disease (p < 0.05), female gender (p < 0.05) and new onset angina.
These data support the concept that, although coronary angioplasty is used in an increased number of patients with more extensive disease, its effectiveness has improved; the procedure, however, has an associated complication rate that, although small, is not negligible.
- Received February 29, 1988.
- Revision received June 8, 1988.
- Accepted June 17, 1988.