Author + information
- David R. Hathaway, MD, FACC∗ and
- Keith L. March, PhD, MD
- ↵∗Address for reprints: David R. Hathaway, MD, Krannert Institute of Cardiology, Department of Medicine, Indianapolis, Indiana 46223.
This review summarizes some of the major advances in the investigation of molecular mechanisms underlying both normal and abnormal cardiovascular function. Four major areas are highlighted including cardiac muscle, the blood vessel, atherosclerosis and thrombosis/thrombolysis. The remarkable strides in understanding multifactorial diseases such as atherosclerosis, and the development of innovative new therapies such as the use of thrombolytic agents produced by recombinant deoxyribonucleic acid (DNA) technology, are noted.
Moreover, it is concluded that the past decade of basic research has provided a solid framework for improvements in the diagnosis and therapy of other forms of cardiovascular disease as well. An evaluation of current trends in basic cardiovascular research suggests that diagnostic and therapeutic approaches to disease will increasingly target specific molecular processes underlyinh the pathophysiologic state.
☆ This study was supported in part by the Herman C. Krannert Fund, Indianapolis; by Grant HL 060308 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; and the American Heart Association, Indiana Affiliate, Indianapolis.
☆☆ We thank Nils Bang, MD, Larry R. Jones, MD, Jon Lindermann, MD and Suzanne B. Knoebel, MD, Department of Medicine, Indiana University School of Medicine, for helpful suggestions and critiques. In addition, we are grateful to Linda Bethuram for editorial assistance.
- Received October 26, 1988.
- Accepted October 31, 1988.