Author + information
- Received October 2, 1989
- Revision received December 22, 1989
- Accepted January 1, 1990
- Published online June 1, 1990.
- Steven Tracy, PhDa,∗,
- Volker Wiegand, Mdb,
- Bruce McManus, MD, PhD, FACCa,
- Charles Gauntt, PhDc,
- Mark Pallansch, PhDd,
- Melinda Beck, PhDa and
- Nora Chapman, PhDa
- ↵∗Address for reprints: Steven Tracy, PhD, Department of Pathology and Microbiology University of Nebraska Medical Center, 600 South 42nd Street, Omaha, Nebraska 68198-6495.
Enteroviruses are thought to be etiologic agents in some cases of human myocarditis and dilated cardiomyopathy. Murine models of acute coxsackievirus E3 myocarditis implicate coxsackie E viruses as possible causes of human myocarditis. Indirect evidence implicating enteroviruses as causative agents in human heart disease derives from serologic studies. More recently, direct evidence for enteroviral presence in diseased human heart tissues has been obtained by nucleic acid hybridization analyses.
Although the data suggest that enteroviral infections may be associated with 18% to 50% of cases of myocarditis or dilated cardiomyopathy, or both, causality has not been established. Unanswered questions remain regarding the specific identity of the enteroviral genomes detected in the human heart and the potential for enteroviruses to persist in the heart.
☆ This work was supported in part by Grant 5-ROI-HL40303-02 from the U.S. Public Health Service, Bethesda, Maryland (Dr. Tracy); by grants from the American Heart Association, Nebraska Affiliate, Omaha (Drs. Beck and McManus) and by the ERACE Foundation of Los Angeles, California and a grant from the American Heart Association, Texas Affiliate, San Antonio (Dr. Gauntt).
- Received October 2, 1989.
- Revision received December 22, 1989.
- Accepted January 1, 1990.