Author + information
- Received November 3, 1989
- Revision received January 31, 1990
- Accepted February 28, 1990
- Published online July 1, 1990.
- ↵∗Address for reprints: Jawahar L. Mehta. MD, PhD, Department of Medicine, Box J-277, JHMHC, University of Florida, Gainesville, Florida 32610.
Recent Investigations of the complex interactions among vascular endothelium, platelets and leukocytes have relevance to the pathogenesis of atherosclerosis and ischemic heart disease. Perturbations in the hemodynamic equilibrium maintained by these cellular elements may lead to vasospasm, in vivo thrombosis and a reduction in blood low. Recent advances in the understanding of these interactions in health and disease slates are summarized. The effect of pharmacologic agents on these cell-cell interactions are discussed to provide the reader with a general understanding of the relevance of these interactions in cardiovascular disease.
↵1 Dr. Mehta is a Clinical Investigator of the Department of Veterans Affairs, Washington, D.C.
☆ This study was supported by funds from the Veterans Affairs Medical Center, Gainesville and American Heart Association, Florida Affiliate, St. Petersburg. Florida.
- Received November 3, 1989.
- Revision received January 31, 1990.
- Accepted February 28, 1990.