Author + information
- Received November 6, 1989
- Revision received February 7, 1990
- Accepted March 7, 1990
- Published online August 1, 1990.
- Linda D. White, MD, MPH∗,†,1,
- Thomas H. Lee, MD, FACC∗∗,†,2,
- E.Francis Cook, ScD∗,‡,
- Monica C. Weisberg, RN∗,
- Gregory W. Rouan, MD§,3,
- Donald A. Brand, PhD∥,
- Lee Goldman, MD, FACC∗,†,
- The Chest Pain Study Group
- ↵∗Address for reprints: Thomas H. Lee, MD, Division of Clinical Epidemiology, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115.
To compare the natural history of patients with new onset ischemic heart disease with that of patients with exacerbations of chronic ischemic heart disease, short- and long-term outcomes of 3,465 emergency room patients with acute ischemic heart disease at four community and three university hospitals were evaluated. Acute myocardial infarction was diagnosed in 598 (33%) of the 1,835 patients with a prior history of infarction or angina and 934 (57%) of the 1,630 without such a history (p < 0.001). Patients with new onset ischemic heart disease with acute myocardial infarction were more likely than patients with infarction and exacerbated chronic ischemic heart disease to have Q wave infarction (57% versus 36%) and to receive thrombolytic therapy (11% versus 5%); they also had higher maximal creatine kinase levels (1,088 ± 1,299 versus 733 ± 906 U/liter) (p < 0.0001 for all three). After adjustment for differences in clinical presentation and initial triage, patients with new onset iscnemic heart disease with acute myocardial infarction were less likely than the comparison group to have congestive complications (odds ratio 0.63, 95% confidence interval 0.47 to 0.84, p < 0.01) but not less likely to have arrhythmic, ischemic or overall complications. Among patients with angina without acute myocardial infarction, patients with new onset ischemic heart disease were less likely to have recurrent ischemic pain and congestive heart failure. In multivariate analysis of longterm follow-up data on 457 patients from one hospital, patients with new onset ischemic heart disease had better cardiovascular survival rates.
These data demonstrate that patients with new onset ischemic heart disease tend to have a better short- and long-term cardiovascular prognosis than do patients with exacerbated chronic ischemic heart disease.
↵1 During the performance of this work, Dr. White was a fellow of the Charles A. Dana Foundation, New York.
↵2 Dr. Lee is the recipient of a Public Health Service Clinical Investigator Award (HL01594-01) from the National Heart, Lung, and Blood Institute, Bethesda, Maryland.
↵3 Dr. Rouan is a Teaching and Research Scholar of the American College of Physicians, Philadelphia, Pennsylvania, and was supported in part by a grant to the Training Program in Clinical Effectiveness from the W.K. Kellogg Foundation, Battle Creek, Michigan.
☆ This study was supported in part by Grant 12543 from the Robert Wood Johnson Foundation, Princeton, New Jersey and Grant 83102-2H from the John A. Hartford Foundation, New York, New York.
- Received November 6, 1989.
- Revision received February 7, 1990.
- Accepted March 7, 1990.