Author + information
- Received March 12, 1990
- Revision received May 29, 1990
- Accepted June 11, 1990
- Published online November 15, 1990.
- ↵∗Address for reprints: Renu Virmani, MD, Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.
Morphologic correlates of pathologic success or failure were studied at autopsy in 28 patients with 40 coronary arteries that had been subjected to balloon angioplasty. The presence of the following histologic features was evaluated: plaque concentricity or eccentricity, calcification, fibrous or fibropultaceous plaque, medial disruption, luminal thrombus and inflammation.
Angioplasty was considered successful (residual cross-sectional luminal area >25%) on pathologic examination in 14 arteries and unsuccessful in 26 arteries. Eccentric plaques were more likely to be successfully dilated than were concentric lesion (p < 0.05). Six (50%) of 12 fibropultaceous plaques were successfully dilated compared with only 8 (21%) of 28 fibrous plaques. Moderate to severe calcification did not preclude morphologic success. Medial stretching or dissection, or both, was more often associated with a successful result. Thus, plaque morphology may be an important determinant of pathologic outcome after coronary angioplasty.
☆ The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense.
- Received March 12, 1990.
- Revision received May 29, 1990.
- Accepted June 11, 1990.