Author + information
- Received April 4, 1990
- Revision received June 20, 1990
- Accepted July 16, 1990
- Published online February 1, 1991.
- Kan Takeda, MD*,1,2,
- Norman D. LaFrance, MD1,
- Harlan F. Weisman, MD, FACC1,
- Henry N. Wagner Jr, MD, FACC1 and
- Lewis C. Becker, MD, FACC†,1
- ↵†Address for reprints: Lewis C. Becker, MD, The Johns Hopkins Hospital, Halsted 500, 600 North Wolfe Street, Baltimore, Maryland 21205.
Recent imaging studies suggest that technetium-99m (Tc-99m) pyrophosphate yields a considerably larger estimate of myocardial infarct size than does indium-111 (In-111) monoclonal antimyosin antibody. To determine whether Tc-99m pyrophosphate may be taken up by reversibly injured myocytes, particularly in the setting of coronary reperfusion, the tissue localization of Tc-99m pyrophosphate and antimyosin antibody was compared in 11 dogs 24 to 68 h after anterior descending coronary artery occlusion (4 dogs with permanent occlusion, 7 with reperfusion). Technetium-99m pyrophosphate and In-111 antimyosin antibody content was determined in serial 2 to 3 mm wide endocardial and epicardial samples taken through the infarct zone in multiple short-axis left ventricular slices.
The number of samples with increased In-111 antimyosin antibody (defined as ≧ mean + 2 SD of normal) was not significantly different from that with increased Tc-99m pyrophosphate. This was true in both reperfused and nonreperfused infarcts. However, the intensity of uptake of Tc-99m pyrophosphate exceeded that of In-111 antimyosin antibody, particularly in the border zones of reperfused infarcts, and the area with moderate to marked increase in tracer uptake (≥2 times normal) was significantly larger with Tc-99m pyrophosphate than In-111 antimyosin antibody (p < 0.001). A specific zone of abnormal Tc-99m pyrophosphate with normal In-111 antimyosin antibody content could not be identified. Histologic evidence of myocardial necrosis was found in virtually every sample with increased In-111 antimyosin antibody, Tc-99m pyrophosphate, or both.
Thus, the spatial extent of In-111 antimyosin antibody and Tc-99m pyrophosphate uptake was identical in myocardial infarction as measured by ex vivo tissue counting. Larger scintigraphic estimates of infarct size with Tc-99m pyrophosphate are probably due to more intense uptake of Tc-99m pyrophosphate in necrotic myocytes, particularly those located at the infarct boundary, rather than uptake in injured viable tissue.
- Received April 4, 1990.
- Revision received June 20, 1990.
- Accepted July 16, 1990.
- American College of Cardiology Foundation