Author + information
- Received April 8, 1991
- Revision received July 15, 1991
- Accepted August 20, 1991
- Published online February 1, 1992.
- Rebecca T. Hahn, MD, FACC∗,
- Mary J. Roman, MD, FACC,
- Allen H. Mogtadek, MD, FACC and
- Richard B. Devereux, MD, FACC
- ↵∗Address for reprints: Rebecca T. Hahn, MD, Division of Cardiology, St. Luke's/Roosevelt Hospital Center, Amsterdam at 114th Street, New York. New York 10025.
To determine whether aortic root dilation associated with a bicuspid aortic valve occurs independently of valvular hemodynamic abnormality, aortic root dimensions were measured by two-dimensional echocardiogrsphy in 83 adults with a functionally normal (n = 19), mildly regurgitant (n = 26), severely regurgitant (n = 27) or stenotic (n = 11) bicuspid aortic valve and compared with findings in normal subjects matched for age and gender. Aortic root measurements were made at four levels: anulus, sinuses of Valsalva, supraaortic ridge and proximal ascending aorta. Seventy-one percent of patients with a bicuspid aortic valve were men.
When compared with control subjects, all hemodynamic subgroups showed a significantly larger aortic root size at three levels: sinuses of Valsalva, supraaortic ridge and proximal ascending aorta (p < 0.05 to p < 0.001). The prevalence of aortic root enlargement among all hemodynamic subgroups ranged from 9% to 59% at the level of the anulus, 36% to 78% at the sinuses, 47% to 79% at the supraaortic ridge and 50% to 64% in the ascending aorta.
Thus, there is a high prevalence of aortic root enlargement in patients with a bicuspid aortic valve that occurs irrespective of altered hemodynamics or age. These findings support the hypothesis that bicuspid aortic valve and aortic root dilation may reflect a common developmental defect.
- Received April 8, 1991.
- Revision received July 15, 1991.
- Accepted August 20, 1991.