Author + information
- Received July 15, 1991
- Revision received September 18, 1991
- Accepted October 3, 1991
- Published online March 1, 1992.
- James A. Goldstein, MD, FACC1,*,
- James S. Tweddell, MD1,
- Benico Barzilai, MD, FACC1,
- Yoko Yagi, MD1,
- Allan S. Jaffe, MD, FACC1 and
- James L. Cox, MD, FACC1
- ↵*Address for reprints: James A. Goldstein, MD, Cardiovascular Division, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, Saint Louis, Missouri 63110.
To determine whether modulation of systolic ventricular interaction influences right ventricular performance during right heart ischemia, the effects of septal ischemia and inotropic stimulation were studied in 15 dogs in an open chest preparation. Right coronary branch occlusions led to right ventricular dilation and free wall dyskinesia, reversed septal curvature and reduced left ventricular diastolic volume. In systole, the septum thickened but bulged paradoxically into the right ventricle generating an active but depressed right ventricular systolic pressure (28.9 ± 5.5 to 22.1 ± 4.5 mm Hg), with associated decreases in right ventricular stroke work (5.66 ± 0.94 to 1.92 ± 0.53 g m/m2) and left ventricular systolic pressure (123 ± 11 to 80 ± 10 mm Hg).
Septal ischemia induced systolic septal thinning, left ventricular dilation and decreased left ventricular systolic pressure (80 ± 10 to 55 ± 10 mm Hg) and stroke work. Although the extent of paradoxic septal displacement increased, there were further dec- rements in right ventricular systolic pressure (22.1 ± 4.5 to 18.7 ± 4.3 mm Hg) and stroke work (1.92 ± 0.53 to 0.7 ± 0.2 g·m/m2).
Dopamine infusion augmented left ventricular free wall contraction and increased left ventricular systolic pressure (55 ± 10 to 172 ± 17 mm Hg) and stroke work. Although systolic septal thinning persisted, the extent of paradoxic septal displacement increased strikingly and, despite continued right ventricular free wall dyskinesia, right ventricular systolic pressure increased (18.7 ± 4.3 to 39.6 ± 6.2 mm Hg) as did right ventricular stroke work (0.7 ± 0.2 to 7 ± 1.6 g·m/m2).
Therefore, the magnitude of systolic interaction is an important determinant of right ventricular performance during right heart ischemia. Septal dysfunction diminishes this interaction, whereas inotropic stimulation augments this compensatory mechanism.
- Received July 15, 1991.
- Revision received September 18, 1991.
- Accepted October 3, 1991.
- American College of Cardiology Foundation