Author + information
- Received June 12, 1991
- Revision received October 15, 1991
- Accepted October 23, 1991
- Published online April 1, 1992.
- Benno J. Rensing, MD,
- Walter R.M. Hermans, MD,
- Jaap W. Deckers, MD, PhD,
- Pim J. de Feyter, MD, PhD, FACC,
- Jan G.P. Tijssen, PhD and
- Patrick W. Serruys, MD, PhD, FACC∗
- ↵∗Address for reprints: Patrick W. Serruys, MD, PhD, Catheterization Laboratory, Thoraxcenter, Erasmus University, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
To determine whether significant angiographic narrowing and restenosis after successful coronary balloon angioplasty is a specific disease entity occurring in a subset of dilated lesions or whether it is the tail end of a gaussian distributed phenomenon, 1,445 successfully dilated lesions were studied before and after coronary angioplasty and at 6-month follow-up study. The original cohort consisted of 1,353 patients of whom 1,232 underwent repeat angiography with quantitative analysis (follow-up rate 91.2%). Quantitative angiography was carried out off-line in a central core laboratory with an automated edge detection technique. Analyses were performed by analysts not involved with patient care.
Distributions of minimal lumen diameter before angioplasty (1.03 ± 0.37 mm), after angioplasty (1.78 ± 0.36 mm) and at 6-month follow-up study (1.50 ± 0.57 mm) as well as the percent diameter stenosis at 6-month follow-up study (44 ± 19%) were assessed. The change in minimal lumen diameter from the post-angioplasty angiogram to the follow-up angiogram was also determined (−0.28 ± 0.52 mm). Seventy lesions progressed toward total occlusion at follow-up. All observed distributions approximately followed a normal or gaussian distribution.
Therefore, restenosis can be viewed as the tail end of an approximately gaussian distributed phenomenon, with some lesions crossing a more or less arbitrary cutoff point, rather than as a separate disease entity occurring in some lesions but not in others.
- Received June 12, 1991.
- Revision received October 15, 1991.
- Accepted October 23, 1991.