Author + information
- Received August 21, 1991
- Revision received November 8, 1991
- Accepted November 22, 1991
- Published online May 1, 1992.
- ↵∗Address for reprints: Peter K. Mazeika, MRCP, Clinical Research Fellow, Clinical Cardiology Unit, Hammersmith Hospital and RPMS, 150 Du Cane Road, London, W12 ONN, England.
Stress echocardiography with dobutamine infusion for detection of coronary artery disease is a potential alternative to exercise stress testing with some theoretic advantages. Fifty patients who were not receiving cardioactive medication were prospectively studied with two-dimensional echocardiography and 12-lead electrocardiography (ECG) during incremental dobutamine infusion (5, 10, 15 and 20 μg/kg body weight per min, each dose for 8 min). Images were analyzed by using an 11-segment left ventricular model. All patients underwent correlative exercise ECG and coronary angiography, which revealed normal coronary arteries in 14 and significant disease (≥70% diameter stenosis) in 36.
Peak rate-pressure product during dobutamine infusion was 18,845 ± 4,156 versus 23,740 ± 6,158 mm Hg/min on exercise (p < 0.01). Interobserver concordance for wall motion analysis was good (kappa coefficient = 0.77). The use of baseline (n = 14) or reversible (n = 24) regional asynergy to define an abnormal dobutamine echocardiogram resulted in a sensitivity for detecting coronary artery disease of 78% and a specificity of 93%. Corresponding data for the dobutamine ECG were 47% and 71% and for the exercise ECG were 72% and 71%, respectively. The development of new mitral regurgitation on Doppler color flow imaging (n = 4) improved sensitivity to 81% without loss of specificity.
Inducible asynergy or new mitral regurgitation was observed in 6 (50%) of 12 patients with single-, 6 (60%) of 10 with double-and 12 (86%) of 14 with triple-vessel disease. The site of transient asynergy provided additional localizing information. Exercise duration and time to diagnostic ST segment shift were shorter in patients with coronary artery disease with versus those without echocardiographic evidence of ischemia (both p < 0.05). Side effects during dobutamine infusion were mild and short-lived.
Dobutamine stress echocardiography is well tolerated, is useful for detection and assessment of coronary artery disease and is applicable to patients unable to exercise.
↵1 Dr. Mazeika is a CORDA research fellow.
☆ This study was funded by a grant from the Coronary Artery Disease Research Association (CORDA, Registered Charity No. 271070, Grant No. 3/90). Tavistock House North, Tavistock Square, London, England. Additional support was obtained from Eli Lilly and Company Limited, Basingstoke, Hampshire, England.
- Received August 21, 1991.
- Revision received November 8, 1991.
- Accepted November 22, 1991.