Author + information
- Arnold M. Katz, MD, FACC*
- ↵*Address for reprints: Arnold M. Katz, MD, Division of Cardiology, Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06032.
Agents that increase cellular cyclic adenosine monophosphate (cyclic AMP) levels exert several effects on cardiac function. These include increases in heart rate and both the force of contraction and rate of relaxation. The latter effects, which might appear to be contradictory, actually represent essential components of the response needed to allow the heart to increase its stroke volume when heart rate is accelerated. This article reviews the mechanisms by which cyclic AMP exerts both contraction-promoting and relaxation-promoting effects in the integrated response of the heart to sympathetic stimulation.
Preperation of this manuscript was made possible by this manuscript was made possible by support from Research Grants HL-21812, HL-22135 and HL-26903 from the National Institutes of Health, Bethesda, Maryland, and a fund established at the University of Connecticut in memory of Stuart F. Wilson.
- American College of Cardiology Foundation