Author + information
- Richard Grose, MD, FACC*,
- Janet Strain, MD and
- Tada Yipintosoi, MD, PhD
- ↵*Address for reprints: Richard Grose, MD, Division of Cardiology, Montefiore Hospital and Medical Center, 111 East 210 Street, Bronx, New York 10467.
Right ventricular angiography was performed in 46 patients with acquired valvular heart disease and 8 normal subjects. Right ventricular ejection fraction (RVEF) correlated highly only with right ventricular peak systolic pressure (RVPSP) and mean pulmonary artery pressure, both in patients with and without tricuspid insufficiency. For the group, RVEF = -0.33 RVPSP + 63 (correlation coefficient [r] = -0.76, probability [p]<0.001). Of 20 patients with moderate or severe elevation of pulmonary artery pressure, 17 (85%) had an abnormally low ejection fraction (<47%), while 19 (73%) of 26 patients with normal or mildly elevated pulmonary artery pressure had a normal right ventricular ejection fraction.
In seven patients with elevated pulmonary artery pressure, a second ventriculogram was performed during intravenous nitroglycerin administration. Nitroglycerin produced a significant decrease in right ventricular peak systolic pressure (59 ± 22 to 49 ± 18 mm Hg, mean ± standard deviation) (p<0.05) and in end-systolic volume (71 ± 16 to 59 ± 11 ml/m2) (p<0.05), and an increase in ejection fraction (43 ± 9 to 48 ± 7%) (p<0.05). Thus, at least part of the depression of ejection fraction in patients with elevated pulmonary pressure is reversible with a decrease in pulmonary artery pressure.
- American College of Cardiology Foundation