Author + information
- Received January 24, 1983
- Revision received March 21, 1983
- Accepted March 30, 1983
- Published online August 1, 1983.
- James A. Goldstein, MD*,
- Gus J. Vlahakes, MD,
- Edward D. Verrier, MD,
- Nelson B. Schiller, MD, FACC,
- Eli Botvinick, MD, FACC,
- John V. Tyberg, MD, FACC,
- William W. Parmley, MD, FACC and
- Kanu Chatterjee, MB, FRCP, FACC1
- ↵1Address for reprints: Kanu Chatterjee, MB, FRCP, Division of Cardiology, Moffitt 1186, University of California, San Francisco, California 94143.
To evaluate the effect of volume loading in the low output state associated with right ventricular infarction, isolated right ventricular infarction was produced in seven dogs with the pericardium intact. Volume loading and pericardiotomy were then sequentially performed. After the production of right ventricular infarction, right ventricular systolic pressure decreased by 25%, aortic pressure by 36% and cardiac output by 32%. Right ventricular ejection fraction decreased by 57%, but left ventricular ejection fraction did not change significantly. Left ventricular transmural pressure and diastolic size decreased, and right ventricular diastolic size increased. Intrapericardial pressure increased and equalization of diastolic pressures was noted. Volume loading resulted in increased right ventricular systolic pressure and stroke work, increased aortic pressure and cardiac output and increased transmural pressure and diastolic size in both ventricles. Pericardiotomy resulted in further increases in right and left ventricular filling, stroke work and cardiac output, as well as resolution of equalized diastolic pressures.
These results indicate that cardiac output in experimental right ventricular infarction increases with volume loading, which enhances left ventricular preload by augmenting right ventricular output. Elevated intrapericardial pressure affects filling of both ventricles and may play a role in the pathophysiology of low cardiac output in right ventricular infarction.
- Received January 24, 1983.
- Revision received March 21, 1983.
- Accepted March 30, 1983.
- American College of Cardiology Foundation