Author + information
- Received October 14, 1982
- Revision received February 9, 1983
- Accepted February 9, 1983
- Published online August 1, 1983.
- Joseph J. Marcella, MD,
- Philip C. Ursell, MD1,*,
- Mark Goldberger, MD,
- William Lovejoy, MD,
- John J. Fenoglio Jr., MD, FACC and
- Melvin B. Weiss, MD, FACC
- ↵1Address for reprints: Philip C. Ursell, MD, Department of Pathology, Presbyterian Hospital, 630 West 168 Street, New York, New York 10032.
Kawasaki syndrome, an acute systemic inflammatory illness of unknown origin usually affecting children, may develop into a serious illness complicated by coronary artery aneurysms or myocarditis. This report describes an adult with Kawasaki syndrome studied by right ventricular endomyocardial biopsy and cardiac catheterization during the acute and recovery phases of illness. The initial biopsy specimen showed acute myocarditis and was associated with hemodynamic evidence of biventricular dysfunction, a severely depressed left ventricular ejection fraction and global hypokinesia. With time, there was spontaneous and rapid resolution of the inflammatory cell infiltrate with concurrent return to normal myocardial function. Right ventricular endomyocardial biopsy studies early in the course of the cardiac disease associated with Kawasaki syndrome may correlate with ventricular function and may be useful for monitoring immunosuppressive therapy in patients with this syndrome.
↵* Present address: 811 Fifth Avenue, Fort Worth, Texas.
This study was supported in part by Grant HL26588 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland
- Received October 14, 1982.
- Revision received February 9, 1983.
- Accepted February 9, 1983.
- American College of Cardiology Foundation