Author + information
- Received August 7, 1992
- Revision received November 4, 1992
- Accepted December 1, 1992
- Published online July 1, 1993.
- Barry S. George, MD, FACC∗,
- Gary S. Roubin, MBBS, PhD, FACC,
- Neal E. Fearnot, PhD,
- Cass A. Pinkerton, MD, FACC,
- Albert E. Raizner, MD, FACC,
- Spencer B. King, MD, FACC,
- David R. Holmes, MD, FACC,
- Eric J. Topol, MD, FACC,
- Dean J. Kereiakes, MD, FACC and
- Geoffrey O. Hartzler, MD, FACC
- ↵∗Address for correspondence: Barry S. George, MD, Midwest Cardiology Research Foundation, 3400 Olentangy River Road, Columbus, Ohio 43214.
- William D. Voorhees III, PhD∗
Objectives. This study reports on the initial experience with the Gianturco-Roubin flexible coronary stent. The immediate and 6-month efficacy of the device and the incidence of the complications of death, myocardial infarction, emergency coronary artery bypass surgery and recurrent ischemic events are presented.
Background. Abrupt or threatened vessel closure after coronary angioplasty is associated with increased risk of myocardial infarction, emergency coronary artery bypass graft surgery and in-hospital death. When dissection or prolapse of dilated plaque into the lumen is unresponsive to additional or prolonged balloon catheter inflation, coronary stenting offers a nonsurgical mechanical means to rapidly restore stable vessel geometry and adequate coronary blood flow.
Methods. From September 1988 through June 1991, 518 patients underwent attempted coronary stenting with the 20-mm long Gianturco-Roubin coronary stent for acute or threatened vessel closure after angioplasty. In 494 patients, one or more stents were deployed. Thirty-two percent of patients received stents for acute closure and 69% for threatened closure.
Results. Successful deployment was achieved in 95.4% of patients. Overall, stenting resulted in an immediate angiographic improvement in the diameter stenosis from 63 ± 25% before stenting to 15 ± 14% after stenting. Emergency coronary artery bypass graft surgery was required in 4.3% (21 of 493 patients). The incidence of in-hospital myocardial infarction (Q wave and non-Q wave) was 5.5% (27 of 493 patients). At 6 months, myocardial infarction was infrequent, occurring in 1.6% (8 of 493 patients). The incidence of in-hospital death was 2.2% (11 of 493 patients). Late death occurred in 7 patients (1.4%) and 34 patients (6.9%) required later bypass graft surgery. Complications included blood loss, primarily from the access site, and subacute thrombosis of the stented vessel in 43 patients (8.7%).
Conclusions. The early multicenter experience suggests that this stent is a useful adjunct to coronary angioplasty to prevent or minimize complications associated with flow-limiting coronary artery dissections previously correctable only by surgery. Although this study was not randomized, it demonstrated a high technical success rate and encouraging results with respect to the low incidence of emergency coronary artery bypass graft surgery and myocardial infarction.
☆ A complete list of participating centers appears in the Appendix. This study was supported in part by funding from Cook Incorporaled, Bloomington, Indiana.
- Received August 7, 1992.
- Revision received November 4, 1992.
- Accepted December 1, 1992.