Author + information
- Received August 28, 1992
- Revision received December 7, 1992
- Accepted January 20, 1993
- Published online August 1, 1993.
- Tomas Vybiral, MD∗,1,
- Donald H. Glaeser, DSc1,
- Ary L. Goldberger, MD∗,1,
- David R. Rigney, PhD∗,1,
- Kenneth R. Hess, PhD1,
- Joseph Mietus, BS∗,
- James E. Skinner, PhD1,
- Marilyn Francis, RN1 and
- Craig M. Pratt, MD, FACC1
- ↵∗Address for correspondence: Tomas Vybiral, MD, Hugh Chatham Memorial Hospital, Parkwood Drive, Elkin, North Carolina 28621.
Objectives. The purpose of this report was to study heart rate variability in Holter recordings of patients who experienced ventricular fibrillation during the recording.
Background. Decreased heart rate variability is recognized as a long-term predictor of overall and arrhythmic death after myocardial infarction. It was therefore posttulated that heart rate variability would be lowest when measured immediately before ventricular fibrillation.
Methods. Conventional indexes of heart rate variability were calculated from Holter recordings of 24 patients with structural heart disease who had ventricular fibrillation during monitoring. The control group consisted of 19 patients with coronary artery dipease, of comparable age and left ventricular ejection fraction, who had nonsustained ventricular tachycardia but no ventricular fibrillation.
Results. Heart rate variability did not differ between the two groups, and no consistent trends in heart rate variability were observed before ventricular fibrillation occurred.
Conclusions. Although conventional heart rate variability is an independent long-term predictor of adverse outcome after myocardial infarction, its clinical utility as a short-term predictor of life-threatening arrhythmias remains to be elucidated.
↵1 Drs. Goldberger and Rigney are supported in part by the National Institutes of Health (R01 HL/MH42172 and P30-AG08812), Bethesda, Maryland; the National Aeronautics and Space Administration (NAG 9-572), Houston, Texas; the National Institute on Drug Abuse (P01-DA06316), Bethesda, Maryland; and the G. Harold and Leila Y. Mathers Charitable Foundation, Mount Kisco, New York.
☆ This work was presented in part at the 64th Annual Scientific Sessions of the American Heart Association, Anaheim, California, November 1991.
- Received August 28, 1992.
- Revision received December 7, 1992.
- Accepted January 20, 1993.