Author + information
- Received April 22, 1993
- Revision received July 23, 1993
- Accepted August 13, 1993
- Published online January 1, 1994.
- Charles Antzelevitch, PhD∗ and
- Serge Sicouri, MD
- ↵∗Address for correspondence: Dr. Charles Antzelevitch, Masonic Medical Research Laboratory, 2150 Bleecker Street, Utica, New York 13504.
Recent findings point to an importment heterogeneity in the electrical behavior of cells spanning the ventricular wall as well as importent differences in the response of the various cell types to cardioactive drugs and pathophysiologic states. These observations have permitted a fine tuning and, in some cases, a reevaluation of basic concepts of arrhythmia mechanisms. This brief review examines the implications of some of these new findings within the scope of what is already kaown about early and delayed afterdepolarizations and triggered activity and discusses the possible relevance of these mechanisms to clinical arrhythmias.
☆ This study was supported in part by Grants HL37396 and HL47678 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; the Charles L. Keith and Clara Miller Foundation, New York, New York; the Eighth Masonic District of Manhattan and the Seventh Manhattan Masonic District Association, Inc., New York, New York.
- Received April 22, 1993.
- Revision received July 23, 1993.
- Accepted August 13, 1993.