Author + information
- Received March 4, 1993
- Revision received October 4, 1993
- Accepted October 14, 1993
- Published online March 1, 1994.
- Pablo A. Chiale, MD∗,
- Ruben A. Sanchez, MD,
- David A. Franco, MD,
- Marcelo V. Elizari, MD, FACC and
- Mauricio B. Rosenbaum, MD, FACC
- ↵∗Address for correspondence: Dr. Pablo A. Chiale, Division of Cardiology. Ramos Mejia Hospital, Urquiza 609, 1st floor, Buenos Aires (1221), Argentina.
Objectives. The aim of this study was to assess the response of refractoriness in normal and diseased human bundle branches to changes in cycle length, as well as during a long period of continuous overdrive pacing.
Background. The anterograde refractory period of the bundle branches in patients with functional bundle branch block shortens as the rate is increased. The rate-dependent response of refractoriness in diseased bundle branches is quite different. However, this difference has not been precisely delineated, and its physiologic meaning is uncertain.
Methods. Refractoriness of the bundle branches was measured by the extrastimulus technique in 16 patients with tachycardia-dependent bundle branch block and 10 patients with functional bundle branch block, both after basic trains of 8 atrial-paced impulses at different cycle lengths and during a 10-min period of continuous overdrive pacing.
Results. The baseline refractory period in the bundle branches of patients with functional bundle branch block measured 430 ±32 ms (mean ± SD) and shortened to 368 ± 30 ms at the shortest cycle length. The maximal effect was reached within the 1st min of overdrive pacing. The baseline refractory period of the bundle branches was significantly longer in patients with tachycardia-dependent bundle branch block (611 ± 184 ms) and demonstrated a cumulative overdrive prolongation in 15 (83%) of 18 studies with typical manifestations of fatigue. In two other studies, this occurred only after ajmaline administration.
Conclusions. A rate- and time-dependent prolongation of refractoriness frequently occurs in diseased human bundle branches. When absent, this response may be induced under the effects of sodium channel blockers. This would suggest that an abnormality in the recovery from inactivavion of the sodium channel might underlie the early stages of bundle branch disease.
☆ This work was supported in part by the Fundacion de Investigaciones Cardiologicas Einthoven, the Fundacion Alberto J. Roemmers and the Consejo Nacional de Investigations Cientificas y Tecnicas (CONICET), Buenos Aires, Argentina.
- Received March 4, 1993.
- Revision received October 4, 1993.
- Accepted October 14, 1993.