Author + information
- Received September 24, 1992
- Revision received November 18, 1993
- Accepted November 24, 1993
- Published online April 1, 1994.
- Javier Botas, MDa,b,1,
- David A. Clark, MD, FACCa,b,
- Fausto Pinto, MDa,b,
- Adrian Chenzbraun, MDa,b and
- Tim A. Fischell, MD, FACC∗,a,b
- ↵∗Address for correspondence: Dr. Tim A. Fischell, Vanderbilt University Medical Center, Division of Cardiology, Medical Center North, CC-2218, Nashville, Tennessee 37232.
Objectives. The purpose of this study was to evaluate the hypothesis that the increase in lumen area induced by percutaneous transluminal coronary angioplasty is secondary to a change in lesion (segmental) distensibility.
Background. Despite the widespread use of coronary angioplasty, the precise mechanism (or mechanisms) of lumen area improvement remains poorly understood.
Methods. Quantitative coronary angiography was used to measure the minimal (contrast agent filled) balloon diameters at 1 to 5 atm, inclusive, during the first and final balloon inflations in 24 lesions successfully treated with coronary angioplasty. To rule out possible confounding effects due to changes in balloon material distensibility during repeated inflations, five control balloons were studied ex vivo. In parallel, intravascular ultrasound imaging was utilized to compare the segmental distensibility (change in lumen area during the cardiac cycle) of eight disease-free and seven mildly diseased coronary segments and seven segments after successful balloon angioplasty.
Results. Minimal balloon diameters increased significantly between the first and final inflations (46%, 33%, 26%, 14% and 10% at 1, 2, 3, 4 and 5 atm, respectively, all p < 0.0001), demonstrating an increase in arterial distensibility after successful coronary angioplasty. No significant changes in balloon diameters were observed during sequential initial inflations at 1 and 2 atm (n = 5). Minimal increases in Balloon diameters were observed during repeated balloon inflations in the ex vivo studies (4.9 ± 1% [mean ± SEM]). A distensibility index, derived from the intravascular ultrasound data, was not different between the balloon-dilated and the normal segments but was significantly lower in mildly diseased sites (14.7 ± 2.2 vs. 12.9 ± 1.2 vs. 6.9 ± 1.9, respectively, p < 0.05) despite a smaller plaque area (7.3 ± 1 vs. 11.3 ± 1 mm2, proximal/nondilated vs. dilated segments, respectively, p < 0.05).
Conclusions. Coronary distensibility is significantly impaired in atherosclerotically diseased coronary segments and increases significantly after balloon angioplasty. This increase in segmental coronary compliance after coronary angioplasty may create a larger lumen area by allowing the vessel to distend in response to normal intraarterial pressure.
↵1 Dr. Botas is the recipient of Grant 92/5228 from the Fondo de Investigacions Cientificas de la Seguridad Social (FISS) and a grant from the Fundacion MAPFRE Medicina, Spain.
☆ This study was presented in part at the 64th Annual Scientific Sessions of the American Heart Association, Anaheim, California, November 1991. It was supported in part by a Clinical Investigator Award (Dr. Fischell): Grant I K08 HL-02001-01. National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
- Received September 24, 1992.
- Revision received November 18, 1993.
- Accepted November 24, 1993.