Author + information
- Received July 30, 1993
- Revision received May 5, 1994
- Accepted May 10, 1994
- Published online October 1, 1994.
- Scott M. Sharp, MD,
- Stephen G. Sawada, MD,FACC∗,
- Douglas S. Segar, MD,FACC,
- Thomas Ryan, MD,FACC,
- Roxanne Kovacs, BS,RN,
- Naomi S. Fineberg, PhD and
- Harvey Feigenbaum, MD,FACC
- ↵∗Address for correspondence: Dr. Stephen G. Sawada, Indiana University Hospital, Room 5420, 926 West Michigan Street, Indianapolis, Indiana 46202-5250.
Objectives. This study attempted to determine the safety and accuracy of dobutamine stress echocardiograpby for detection of coronary artery disease in patients with dilated cardiomyopathy.
Background. Detection of regional wall motion abnormalities at rest does not reliably distinguish ischemic front nonischemic cardiomyopathy. Previous studies have shown that dobutamine stress echocardiography safely and accurately identifies coronary artery disease in patients without dilated cardiomyopathy.
Methods. Seventy patients with dilated cardiomyopathy under-went dobutamine stress echocardiography. Echocardiograms were obtained at baseline and at low (5 to 10 μg/kg body weight per min) and peak doses of dobutamine. Rest and stress left ventricular wall motion scores were derived from analysis of regional wall motion. Fifty-four subjects underwent coronary angiography.
Results. Dobutamine infusion was terminated after achievement of the target heart rate or maximal protocol dose in 49 patients (70%), ischemia in 12 (17%), arrhythmia in 4 (6%) and side efects in 5 (7%). No patient had prolonged ischemia or sustained arrhythmia. Of those with angiographic studies, 40 had significant coronary artery disease (≥50% diameter stenosis). Use of the change in global wall motion score index from low to peak dose resulted in a sensitivity of 83% for dobutamine stress echocardiography and a specificity of 71% for detection of coronary artery disease. Sensitivity for detection of triple-,double-and single-vessel disease was 100%, 83% and 69%, respectively.
Conclusions. Dobutamine stress echocardiography safely provides diagnostic information in patients with dilated cardiomyopathy. This technique has high sensitivity for multivessel coronary artery disease but only moderate specificity.
☆ This study was supported in part by the Herman C. Krannert Fund. Indianapolis, Indiana; by Grants HL-06308 and HL-07182 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland; and by the American Heart Association, Indiana Affiliate, Indianapolis, Indiana. This study was presented in part at the 64th Annual Scientific Sessions of the American Heart Association, Anaheim, California, November 1991.
- Received July 30, 1993.
- Revision received May 5, 1994.
- Accepted May 10, 1994.