Author + information
- Received July 1, 1994
- Revision received September 29, 1994
- Accepted October 7, 1994
- Published online March 1, 1995.
- Maurice Enriquez-Sarano, MD, FACC*,
- Fletcher A. Miller Jr., MD, FACC,
- Sharonne N. Hayes, MD, FACC,
- Kent R. Bailey, PhD,
- A. Jamil Tajik, MD, FACC and
- James B. Seward, MD, FACC
- ↵*Address for correspondence: Dr. Maurice Enriquez-Sarano, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905.
Objectives. We attempted to determine the accuracy and pitfalls of calculating the mitral regurgitant orifice area with the proximal isovelocity surface area method in a clinical series that included patients with valvular prolapse and eccentric jets.
Background. The effective regurgitant orifice area, a measure of lesion severity of mitral regurgitation, can be calculated by the proximal isovelocity surface area method, the accuracy and pitfalls of which have not been established.
Methods. In 119 consecutive patients with isolated mitral regurgitation, effective regurgitant orifice area was measured by the proximal isovelocity surface area method and compared with measurements simultaneously obtained by quantitative Doppler and quantitative two-dimensional echocardiography.
Results. The effective mitral regurgitant orifice area measured by the proximal isovelocity surface area method tended to be overestimated compared with that measured by quantitative Doppler and quantitative two-dimensional echocardiography (38 ± 39 vs. 36 ± 33 mm2[p = 0.09] and 34 ± 32 mm2[p = 0.02], respectively). Overestimation was limited to patients with prolapse (61 ± 43 vs. 56 ± 35 mm2[p = 0.05] and 54 ± 34 mm2[p = 0.014]) and was restricted to patients with nonoptimal flow convergence (n = 7; 137 ± 35 vs. 84 ± 34 mm2[p = 0.002] and 79 ± 33 mm2[p = 0.002]). In patients with optimal flow convergence (n = 112), excellent correlations with both reference methods were obtained (r = 0.97, SEE 6 mm2and r = 0.97, SEE 7 mm2, p < 0.0001).
Conclusions. In calculating the mitral effective regurgitant orifice area with the proximal isovelocity surface area method, the observed pitfall (overestimation due to nonoptimal flow convergence) is rare. Otherwise, the method is reliable and can be used clinically in large numbers of patients.
- Received July 1, 1994.
- Revision received September 29, 1994.
- Accepted October 7, 1994.
- American College of Cardiology