Author + information
- Received June 6, 1995
- Revision received November 21, 1995
- Accepted January 30, 1996
- Published online June 1, 1996.
- Robert K.M. Chan, MBBS,FRACP,
- Kenneth J. Lee, MBBS,FRACP,
- Paul Calafiore, MBBS,FRACP,
- Salvatore U. Berlangieri, MBBS,FRACP,
- W. John McKay, MBBS,FRACP and
- Andrew M. Tonkin, MD,FRACP∗
- ↵∗Address for correspondence: Dr. Andrew Tonkin, Department of Cardiology, Austin and Repatriation Medical Center, Austin Campus, Heidelberg, Victoria 3084, Australia.
Objectives. The aim of this study was to correlate dobutamine-induced contractile reserve as detected by echocardiography with findings on positron emission tomography in patients with chronic ischemic left ventricular dysfunction.
Background. Contractile reserve induced by low dose dobutamine infusion has been proposed as a marker of myocardial viability.
Methods. Sixty patients with stable coronary artery disease and left ventricular dysfunction (mean ejection fraction [± SD] 29 ± 10%) underwent transthoracic echocardiography with dobutamine infusion (up to 10 μg/kg body weight per min) and positron emission tomography with nitrogen-13 ammonia and fluorine-18 (F-18) fluorodeoxyglucose as a perfusion and a metabolic tracer, respectively. Regional wall motion, perfusion and metabolism were analyzed semiquantitatively by using a 16-segment model. Segments with F-18 fluorodeoxyglucose uptake > 50% were considered viable on positron emission tomography.
Results. After dobutamine infusion, hemodynamic variables changed significantly, and myocardial ischemia was evident in 17 patients. All 60 patients had dysfunctional myocardium considered viable on positron emission tomography (8 ± 4 segments/patient), whereas 52 patients had dysfunctional myocardium with contractile enhancement by dobutamine echocardiography (4 ± 2 segments/patient, p = 0.01). The extent of dysfunctional myocardium with contractile reserve appeared to correlate less closely with the total extent of viable dysfunctional myocardium identified by positron emission tomography than with the number of such segments associated with a pattern of perfusion-metabolism mismatch.
Conclusions. In patients with chronic ischemic left ventricular dysfunction, echocardiography can be used to identify enhancement in the contractile function of viable dysfunctional myocardium after infusion of low dose dobutamine. In this study, the presence and extent of such enhancement were relatively less than the values obtained from positron emission tomography.
☆ This work was supported by a Postgraduate Medical Research Scholarship from the National Health and Medical Research Council of Australia, Canberra (Dr. Chan).
- Received June 6, 1995.
- Revision received November 21, 1995.
- Accepted January 30, 1996.