Author + information
- Received September 25, 1995
- Revision received February 21, 1996
- Accepted March 4, 1996
- Published online July 1, 1996.
- Albert Varga, MD∗,
- Eugenio Picano, MD, PhD, FESC,
- Lauro Cortigiani, MD,
- Nunzia Petix, MD,
- Franca Margaria, MD,
- Ornella Magaia, MD,
- Joanna Heyman, MD,
- Riccardo Bigi, MD,
- Wilson Mathias Jr., MD,
- Guido Gigli, MD,
- Patrizia Landi,
- Mauro Raciti,
- Alessandro Pingitore, MD,
- Rosa Sicari, MD,
- EPIC (Echo Persantine International Cooperative),
- EDIC (Echo Dobutamine International Cooperative) Study Groups
- ↵∗Address for correspondence: Dr. Albert Varga, c/o Dr. Eugenio Picano. CNR Institute of Clinical Physiology, Via Paolo Savi, 8, 56123 Pisa, Italy.
Objectives. We sought to assess whether the site of future myocardial infarction can be predicted on the basis of induced dyssynergy (“area at risk”) recognized by stress echocardiography.
Background. The severity and extent of stress-induced dyssynergy are strong predictors of subsequent major cardiac events. However, high grade stenotic lesions are not strictly associated with the site of future coronary occlusions.
Methods. From the stress echocardiography multicenter trials data bank, we selected 70 patients (56 men; mean age ± SD 58 ± 11 years) meeting the following inclusion criteria: 1) dipyridamole (n = 53) or dobutamine (n = 17) stress echocardiography; 2) a spontaneously occurring infarction, with no intercurrent revascularization procedure between the initial study and the infarction; and 3) a follow-up rest echocardiogram obtained 41 ± 90 days after the infarction.
Results. A complete ischemia-infarction mismatch (infarct-related dysfunction in a patient with negative stress test results) occurred in 29 patients (41%). A partial mismatch (ischemic dysfunction in a territory different from the infarct area) occurred in nine patients (13%). A match (ischemia-related and infarction-related dyssynergy involving the same region) occurred in 32 patients (46%). The average time interval between the stress examination and the occurrence of infarction or reinfarction was 144 ± 160 days in patients with a match and 439 ± 622 days in patients with a mismatch (p < 0.05).
Conclusions. Induced ischemia (imaged as transient dyssynergy by pharmacologic stress echocardiography) inconsistently identifies the site of future infarction. The majority of spontaneous coronary occlusions leading to infarction unheralded by induced ischemia. However, most infarctions occurring within 1 year of stress testing are in the area identified as ischemic during testing.
☆ A complete list of the EPIC and EDIC Study Group participants appears in References 9 and 13. Dr Varga was supported by the European Society of Cardiology and is from Szent-Gyorgy University of Szeged, Hungary.
- Received September 25, 1995.
- Revision received February 21, 1996.
- Accepted March 4, 1996.