Author + information
- Received December 27, 1995
- Revision received April 3, 1996
- Accepted April 16, 1996
- Published online September 1, 1996.
- Jyri Lommi, M.D.a,1,2,
- Markku Kupari, M.D.a,∗,3,4,
- Pekka Koskinen, M.D.a,
- Hannu Näveri, M.D.a,
- Hannu Leinonen, M.D.a,
- Kari Pulkki, M.D.b and
- Matti Härkönen, M.D.a
- ↵∗Address for correspondence: Dr. Markku Kupari, Division of Cardiology, Helsinki University Central Hospital, FIN-00290, Helsinki, Finland.
Objectives. The present study was designed to assess whether blood ketone bodies are elevated in congestive heart failure (CHF) and whether ketonemia is related to the hemodynamic and neurohumoral abnormalities of CHF.
Background. In CHF, consumption of the body's fat stores may become abnormally high, contributing to the development of cardiac cachexia. Increased mobilization of free fatty acids could, in theory, augment ketogenesis, but whether patients with CHF are prone to ketosis remains unknown.
Methods. Forty-five patients with chronic CHF (mean age [±SD] 57 ± 13 years) and 14 control subjects free of CHF (mean age 53 ± 13 years) underwent invasive and noninvasive cardiac studies and determination of blood ketone bodies (acetoacetate plus beta-hydroxybutyrate), circulating free fatty acids, glucose, lactate, insulin, glucagon, growth hormone, cortisol, norepinephrine, N-terminal proatrial natriuretic peptide, tumor necrosis factor-alpha and interleukin-6 after an overnight fast.
Results. Patients with CHF had elevated blood ketone bodies (median 267 μmol/liter, range 44 to 952) compared with control subjects (median 150 μmol/liter, range 31 to 299, p < 0.05). In the total study group, blood ketone bodies were related to pulmonary artery wedge pressure (rs = 0.45, p < 0.001), left ventricular ejection fraction (rs = −0.37, p < 0.01), right atrial pressure (rs = 0.36, p < 0.01) and circulating concentrations of free fatty acids (rs = 0.52, p < 0.001), glucose (rs = −0.39, p < 0.01), norepinephrine (rs = 0.45, p < 0.001), growth hormone (rs = 0.30, p < 0.05) and interleukin-6 (rs = 0.27, p < 0.05). In multivariate analysis, left ventricular ejection fraction, serum free fatty acids and serum glucose were independent predictors of ketonemia.
Conclusions. Blood ketone bodies are elevated in CHF in proportion to the severity of cardiac dysfunction and neurohormonal activation. This may be at least partly attributable to increased free fatty acid mobilization in response to augmented neurohormonal stimulation. Additional studies are needed to identify the detailed mechanisms and clinical implications of CHF ketosis.
- Received December 27, 1995.
- Revision received April 3, 1996.
- Accepted April 16, 1996.