Author + information
- Received November 28, 1994
- Revision received February 23, 1996
- Accepted May 3, 1996
- Published online September 1, 1996.
- Davendra Mehta, M.D., PhD, F.A.C.C.∗,
- Martin Goldman, M.D., F.A.C.C.,
- Orna David, B.S., R.D.C.S. and
- J.Anthony Gomes, M.D., F.A.C.C.
- ↵∗Address for correspondence: Dr. Davendra Mehta, Box 1030, Division of Cardiology, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, New York 10029.
Objectives. We sought to investigate the relation between signal-averaged electrocardiographic (ECG) variables and the extent of right ventricular disease, as estimated by right ventricular enlargement during detailed echocardiography, in patients with arrhythmogenic right ventricular dysplasia.
Background. In patients with ventricular tachycardia of right ventricular origin, a normal signal-averaged ECG is indicative of “idiopathic” ventricular tachycardia, whereas an abnormal signal-averaged ECG is a specific marker for right ventricular disease, especially dysplasia. Signal-averaged ECGs in these patients are mildly to grossly abnormal.
Methods. Ten patients with the clinical diagnosis of arrhythmogenic right ventricular dysplasia were included. All patients had documented, sustained ventricular tachycardia, no coronary artery disease and a normal QRS duration of ≤110 ms on routine 12-lead electrocardiography. Signal-averaged ECGs were recorded using time-domain analysis. Right ventricular cavity dimensions recorded during two-dimensional echocardiography were measured at the level of the inflow tract, midcavity and outflow tract. Signal-averaged ECG variables and echocardiographic measurements were correlated using linear regression analysis.
Results. Nine of 10 patients had abnormal signal-averaged ECGs. There was a consistent correlation between all signal-averaged ECG variables and the right ventricular cavity dimensions at the level of the midcavity. The correlation was most significant with the duration of the filtered QRS complex (p < 0.001 for QRS duration, p < 0.01 for late potential duration and p < 0.05 for root-mean-square voltage of the last 40 ms). There was no consistent correlation between the signal-averaged ECG variables and right ventricular dimensions at the level of the inflow and outflow tracts.
Conclusions. The majority of patients with arrhythmogenic right ventricular dysplasia have abnormal signal-averaged ECGs. In the absence of bundle branch block, the extent of abnormality of signal-averaged ECG variables is in proportion to right ventricular cavity enlargement, and thus is indicative of the severity of right ventricular dysfunction.
- Received November 28, 1994.
- Revision received February 23, 1996.
- Accepted May 3, 1996.