Author + information
- Received April 15, 1996
- Revision received June 27, 1996
- Accepted July 1, 1996
- Published online November 1, 1996.
- Kiyotaka Kugiyama, MD** (, )
- Hirofumi Yasue, MD,
- Masamichi Ohgushi, MD,
- Takeshi Motoyama, MD,
- Hiroaki Kawano, MD,
- Yoshito Inobe, MD,
- Osamu Hirashima, MD and
- Seigo Sugiyama, MD
- ↵**Address for correspondence: Dr. Kiyotaka Kugiyama, Division of Cardiology, Kumamoto University School of Medicine, Honjo 1-1-1, Kumamoto City, Japan 860.
Objectives. This study sought to examine nitric oxidemediated regulation of epicardial coronary arterial tone in cigarette smokers.
Background. Cigarette smoking is a major risk factor for coronary artery disease and is highly prevalent in patients with coronary spastic angina. Long-term exposure to cigarette smoking has been recently reported to suppress endothelium-dependent arterial relaxation in vivo humans.
Methods. Responses of epicardial coronary artery diameter to single or combined infusion of acetylcholine and NG-monomethyl-l-arginine (L-NMMA) into the left main coronary artery were examined in 11 current smokers and 17 nonsmokers using quantitative coronary angiography.
Results. Acetylcholine dilated one-third of the proximal segments and most of the distal segments of coronary arteries in nonsmokers, whereas it constricted most of the proximal and distal segments in smokers. L-NMMA decreased the basal diameter of coronary arteries in nonsmokers but had minimal effect on the basal diameter in smokers. L-NMMA abolished the dilator response to acetylcholine in the coronary arteries of nonsmokers but had minimal effect on the constrictor response to acetylcholine in the arteries of smokers. The dilator response to nitroglycerin was significantly increased in the coronary arteries of smokers compared with in those of nonsmokers. The constrictor response to L-NMMA at rest was significantly correlated with the dilator response to nitroglycerin and with the diameter changes to acetylcholine in both smokers and nonsmokers.
Conclusions. Nitric oxide bioactivity at rest and at acetylcholinestimulated conditions in smokers was decreased, leading to the supersensitivity of the artery to the dilator effect of nitroglycerin as well as the constrictor effect of acetylcholine in smokers. Cigarette smoking affects nitric oxide-mediated regulation of coronary artery tone.
This study was supported in part by Grants-in-Aid C07670793 from the Ministry of Education, Science, and Culture, Japan and the Smoking Research Foundation Grant for Biomedical Research, Tokyo, Japan and the ONO Medical Research Foundation, Osaka, Japan.
- Received April 15, 1996.
- Revision received June 27, 1996.
- Accepted July 1, 1996.
- American College of Cardiology