Author + information
- Received June 6, 1996
- Revision received September 23, 1996
- Accepted October 9, 1996
- Published online February 1, 1997.
- ↵*Dr. Ian Macdonald, Department of Physiology and Pharmacology, Queen’s Medical Centre, Nottingham NG7, 2UH, England, United Kingdom.
Objectives. This study aimed to explore the hemodynamic responses to ingestion of meals of different composition in patients with chronic stable angina and to assess the effect of these meals on time to onset of >1-mm ST segment depression and limiting angina pectoris during exercise.
Background. To our knowledge, no study has assessed the effect of meal composition and timing of exercise in patients with coronary artery disease.
Methods. Fifteen patients with chronic stable angina visited our laboratory in the fasted state on three occasions. Measurements of cardiac output, heart rate and blood pressure were taken while patients were standing. A modified Bruce exercise test was then carried out, during which time to onset of >1-mm ST segment depression and limiting chest pain were recorded. Patients then ate a 2.5-MJ high fat or high carbohydrate meal; on the third occasion, no meal was taken. At 30 min and 1 h after eating the meals, rest hemodynamic measurements and exercise tests were repeated.
Results. The high fat meal did not affect exercise variables, whereas the high carbohydrate meal resulted in a reduction in time to onset of ST segment depression of 74.4 ± 22.2 s (mean ± SEM) during exercise at 30 min (p < 0.01), and at both 30 and 60 min after the high carbohydrate meal, limiting chest pain occurred 50 to 90 s earlier than when patients fasted (p < 0.01).
Conclusions. One hour after a high carbohydrate meal, the onset of angina during exercise occurs earlier than in the fasted state. Despite similar hemodynamic adjustments, a high fat meal does not affect exercise time.
(J Am Coll Cardiol 1997;29:302–7)
☆ This study was supported by a project grant from the Wellcome Trust, London, England, United Kingdom.
- Received June 6, 1996.
- Revision received September 23, 1996.
- Accepted October 9, 1996.
- The American College of Cardiology