Author + information
- Received March 17, 1983
- Revision received August 10, 1983
- Accepted August 16, 1983
- Published online January 1, 1984.
- Tatsuo Sakamaki, MD,
- Chuwa Tei, MD, FACC1,
- Samuel Meerbaum, PhD, FACC,
- Keicho Shimoura, MD,
- Shuji Kondo, MD,
- Michael C. Fishbein, MD, FACC,
- Jacob Y-Rit, MD,
- Pravin M. Shah, MD, FACC and
- Eliot Corday, MD, FACC*
- ↵*Address for reprints: Eliot Corday, MD, Cedars-Sinai Medical Center, Halper Research Building, 8700 Beverly Boulevard, Los Angeles, California 90048.
Myocardial contrast two-dimensional echocardiography was used in 21 closed chest dogs to assess its ability to delineate the extent of underperfused acutely ischemic myocardium. An agitated saline-Renografin echocardiographic contrast agent was injected into the left main coronary artery after left anterior descending coronary artery occlusion, and the size of the contrast echo-free area characterizing the perfusion defect was outlined in short-axis cross sections of the left ventricle. In 13 dogs, monastral blue dye was injected after 45 minutes of coronary artery occlusion and before sacrifice to provide anatomic delineation of underperfused zones in equivalent sections. Perfusion defects assessed by contrast two-dimensional echocardiography correlated well with those delineated by monastral blue dye (r = 0.91). Contrast echocardiographic study was also performed in eight other dogs at 5 hours of occlusion, after which infarct size was measured with triphenyl-tetrazolium-chloride. Contrast echocardiographic outline of the perfusion deficiency correlated but slightly overestimated the extent of necrosis (r = 0.88).
It is concluded that contrast two-dimensional echocardiography can detect and outline the underperfused “risk area” during acute coronary artery occlusion, and may also permit assessment of the extent of myocardial infarction.
↵1 Dr. Chuwa Tei was a Senior Investigator of American Heart Association, Greater Los Angeles Affiliate, supported in part by a Group Investigatorship Award.
This study was funded in part by Grants HL 17651–08 and HL 14644–09 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland and the Mitchell Family Foundation, the Ah-manson Foundation, The W.M. Keck Foundation, Mrs. Florence Hamilton, Mr. and Mrs. Harry Roman, Mr. and Mrs. Ira Gershwin, Mrs. Sue Cummings, Mrs. Dorothy Forman, Ms. Joan and Mrs. Pearl Borinstein, Mr. J. C. Dunas and the Medallion Group of Cedars-Sinai Medical Center, Los Angeles, California.
- Received March 17, 1983.
- Revision received August 10, 1983.
- Accepted August 16, 1983.
- American College of Cardiology Foundation