Author + information
- Received May 2, 1983
- Revision received September 13, 1983
- Accepted September 30, 1983
- Published online March 1, 1984.
- Djavad T. Arani, MD, FACC,
- David G. Greene, MD, FACC,
- Ivan L. Bunnell, MD, FACC,
- Gretchen L. Smith, RN, MS and
- Francis J. Klocke, MD, FACCa
- ↵aAddress for reprints: Francis J. Klocke, MD, SUNY/B Clinical Center CC-169,462 Grider Street, Buffalo, New York 14215.
Flow per unit weight in collateral-dependent myocardium was quantified selectively in seven patients with complete occlusion of the proximal left anterior descend ing artery and prominent distal collateralization from the right coronary artery by infusing dissolved hydrogen into the right coronary artery for 10 to 15 minutes and monitoring hydrogen desaturation in the great cardiac vein. Coronary flow per unit weight in all myocardium draining into the great cardiac vein was quantified simultaneously by having the patient breathe helium and by monitoring arterial and great cardiac vein helium desaturation. Flow per unit weight in collateral-dependent myocardium averaged 38 ± 8 (standard deviation) ml/min per 100 g and was in each case below the 95% confidence limit for normal individuals with the same rate-pressure product. Flow per unit weight in all myocardium draining into the great cardiac vein was systematically higher (51 ± 8 ml/min per 100 g); because arteries other than the anterior descending had no stenoses greater than 30% in diameter, these values presumably reflect mixtures of subnormally perfused collateralized myocardium and adjacent normally perfused tissue.
The findings suggest that coronary flow per unit weight is not maintained at usual basal values in densely collaterlized myocardium that is entirely collateral-dependent. The reductions in flow are presumably associated with marked reductions in local arterial pressure and raise the possibility of a chronic reduction in local myocardial metabolic demand
This study was supported by Research Grant HLB-15194 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
- Received May 2, 1983.
- Revision received September 13, 1983.
- Accepted September 30, 1983.
- American College of Cardiology Foundation