Author + information
- Received October 17, 1983
- Revision received December 19, 1983
- Accepted December 21, 1983
- Published online June 1, 1984.
- Fetnat M. Fouad, MD, FACCa,
- J. Marek Slominski and
- Robert C. Tarazi, MD, FACC
- ↵aAddress for reprints: Fetnat M. Fouad, MD, Research Division, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106.
Initial studies of diastolic cardiac function in hypertension demonstrated that slowing of the maximal rate of left ventricular filling occurred before alterations in either ejection fraction or cardiac output. The present study was undertaken to determine: 1) the relation between hypertension, increased left ventricular mass and impaired left ventricular filling, and 2) the correlation between abnormalities in left ventricular diastolic function and its systolic performance. Eleven normal subjects (Group 1), 5 hypertensive patients without evidence of left ventricular hypertrophy (Group 2) and 18 hypertensive patients with increased left ventricular mass by echocardiography (Group 3) were studied by M-mode echocardiography, radionuclide (technetium-99m human serum albumin) first pass technique and gated blood pool scintigraphy.
Indexes of systolic function (ejection fraction, maximal rate of ejection and percent left ventricular shortening) were essentially similar in hypertensive and normotensive subjects. No correlation was found between systolic blood pressure and left ventricular mass (r = 0.20, not significant). Maximal rate of left ventricular filling (P dV/dt) and fast filling fraction decreased progressively from Group 1 to Group 3 (2.36 ± 0.4 [mean ± standard deviation], 2.17 ± 0.3 and 1.97 ± 0.4 s-1, respectively, for P dV/dt and 46 ± 7, 48 ± 9 and 38 ± 11% , respectively, for fast filling fraction); the difference from values in normal subjects reached statistical significance in hypertensive patients with left ventricular hypertrophy. Left ventricular maximal filling rate correlated inversely with left ventricular mass and left ventricular end-systolic diameter (r = -0.74), but positively with left ventricular fractional shortening and ejection fraction (r = 0.70).
These results suggest that impairment of early left ventricular filling develops in relation to left ventricular hypertrophy in hypertension and that it can be detected even before definite evidence of systolic cardiac impairment is present.
This study was supported in part from a grant of the American Heart Association, Northeast Ohio Affiliate, Cleveland, Ohio.
- Received October 17, 1983.
- Revision received December 19, 1983.
- Accepted December 21, 1983.
- American College of Cardiology Foundation