Author + information
- Received February 12, 1997
- Revision received July 31, 1997
- Accepted August 21, 1997
- Published online December 1, 1997.
- Yasuhiko Sakata, MDA,*,
- Kazuhisa Kodama, MD, FACCA,
- Masafumi Kitakaze, MD, FACCB,
- Tohru Masuyama, MD, FACCB,
- Atsushi Hirayama, MDA,
- Young-Jae Lim, MDC,
- Fuminobu Ishikura, MDA,
- Akihiko Sakai, MDA,
- Takayoshi Adachi, MDA and
- Masatsugu Hori, MDB ()
- ↵*Dr. Yasuhiko Sakata, The First Department of Medicine, Osaka University School of Medicine, 2-2 Yamada-oka, Suita, 565 Japan.
Objectives. The aim of this study was to investigate the interaction between ischemic preconditioning (IP) and collateral recruitment (CR) during ischemic adaptation in patients.
Background. The mechanism of ischemic adaptation still remains controversial in humans.
Methods. The clinical, electrocardiographic, hemodynamic and echocardiographic responses to three 150-s occlusions of the left anterior descending coronary artery were assessed in relation to CR in 18 patients with effort angina undergoing elective percutaneous transluminal coronary angioplasty.
Results. During the first occlusion, recruitable collateral circulation (RCC) to the occluded myocardium was detected by myocardial contrast echocardiography in 6 patients (Group C) and was not seen in 12 (Group N). In Group N, all patients manifested signs of severe ischemia during each inflation. However, their symptoms and ST segment shift significantly decreased from the first to the third occlusions, suggesting the occurrence of IP. The elevation of mean pulmonary artery pressure and deterioration of anterior wall motion were comparable between the first and the third occlusions in Group N. In contrast, myocardial ischemia was significantly less marked during occlusion in Group C than in Group N, and no preconditioning effect was observed. The extent of RCC did not differ between the first and the third occlusions in each group.
Conclusions. Both IP and CR may play independent roles in ischemic adaptation in humans. With RCC, myocardial ischemia was greatly reduced. Without RCC, preconditioning clinically and electrocardiographically lessened myocardial ischemia but failed to preserve left ventricular function.
- Received February 12, 1997.
- Revision received July 31, 1997.
- Accepted August 21, 1997.
- The American College of Cardiology