Author + information
- Received November 12, 1996
- Revision received December 5, 1997
- Accepted January 23, 1998
- Published online May 1, 1998.
- Nili Zafrir, MDAB,
- Jeffrey A Leppo, MD, FACCC,
- Christopher P Reinhardt, PhDC and
- Seth T Dahlberg, MDC,* ()
- ↵*Dr. Seth T. Dahlberg, Department of Nuclear Medicine, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, Massachusetts 01655.
Objectives. The purpose of this study was to compare thallium reinjection with standard stress/delay redistribution for the prediction of cardiac events.
Background. Although thallium reinjection enhances the detection of viable myocardium, its contribution to prognosis over stress/delay redistribution in a general referral population has not been clearly evaluated.
Methods. This retrospective analysis included 366 consecutive patients with coronary artery disease who underwent stress/delay redistribution imaging and thallium reinjection scintigraphy, with a mean follow-up of 33 ± 12 months.
Results. Cardiac events occurred in 48 patients (40 deaths, 8 myocardial infarctions). Of the 366 original patients, 159 demonstrated ischemia by stress/delay redistribution, 107 showed ischemia by reinjection only, and 100 showed infarction only. Cardiac events occurred in 20 patients (12.6%) with stress/delay redistribution, 13 patients (12%) with ischemia detected by thallium reinjection only and 15 patients (15%) with infarction only. The size of the reversible thallium defect by either stress/delay redistribution imaging or reinjection scintigraphy did not predict cardiac events. Independent predictors of cardiac events included left ventricular cavity size, the size of the abnormal perfusion defect and patient age.
Conclusions. Thallium reinjection does not contribute independent prognostic utility for cardiac events when compared with stress/delay redistribution. Left ventricular dilation and the size of the post-stress defect were predictors of cardiac events.
- Received November 12, 1996.
- Revision received December 5, 1997.
- Accepted January 23, 1998.
- The American College of Cardiology