Author + information
- Received March 13, 1998
- Revision received July 2, 1998
- Accepted July 24, 1998
- Published online November 15, 1998.
- Takeshi Motoyama, MDa,
- Hiroaki Kawano, MDa,
- Kiyotaka Kugiyama, MDa,
- Osamu Hirashima, MDa,
- Masamichi Ohgushi, MDa,
- Ryusuke Tsunoda, MDa,
- Yasushi Moriyama, MDa,
- Yuji Miyao, MDa,
- Michihiro Yoshimura, MDa,
- Hisao Ogawa, MDa and
- Hirofumi Yasue, MDa,*
- ↵*Address for correspondence: Dr. Hirofumi Yasue, Division of Cardiology, Kumamoto University School of Medicine, Honjo 1-1-1, Kumamoto City, Japan 860
Objectives. We examined the effects of oral administration of vitamin E, an antioxidant, on endothelium-dependent vasodilation in patients with coronary spastic angina.
Background. We have recently reported that endothelium-dependent vasodilation is impaired in patients with coronary spastic angina (CSA). Furthermore, it is known that oxidative stress may play an important role in the impairment of endothelium-dependent vasodilation in cardiovascular diseases.
Methods. With the ultrasound technique, flow-dependent vasodilation of the brachial arteries during reactive hyperemia was examined before and after treatment for a month with either oral administration of vitamin E (α-tocopherol acetate, 300 mg/day) or placebo, which is randomly assigned, in patients with CSA (n = 60).
Results. Before treatment, patients with CSA had impaired flow-dependent vasodilation, lower plasma levels of α-tocopherol and higher plasma levels of thiobarbituric acid reactive substances (TBARS), as compared with age- and sex-matched control subjects (n = 60) (flow-dependent vasodilation: 3.1 ± 1.8 vs. 7.1 ± 2.5%, p < 0.001; α-tocopherol levels: 8.9 ± 1.8 vs. 10.8 ± 1.8 μg/ml, p < 0.001). In patients with CSA, treatment with vitamin E restored flow-dependent vasodilation (3.1 ± 1.7 vs. 8.3 ± 2.0%, p < 0.001), and this improvement was associated with the decreases in plasma TBARS levels and anginal attacks.
Conclusions. The results indicate that vitamin E treatment improved endothelium-dependent vasodilation and decreased plasma TBARS levels in patients with CSA. Thus, increased oxidative stress may contribute to endothelial dysfunction and anginal attacks in patients with CSA.
☆ This study was supported in part by grants-in-aid for Scientific Research on Priority Area (03268107), B03454257 and C3670460, from the Ministry of Education, Science, and Culture in Japan and the Smoking Research Foundation, Tokyo, Japan.
- Received March 13, 1998.
- Revision received July 2, 1998.
- Accepted July 24, 1998.
- American College of Cardiology