Journal of the American College of Cardiology
Clinical Studies
Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarctionResults of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) Trial
Kenneth W Mahaffey, Joseph A Puma, N.Alejandro Barbagelata, Marcelo F DiCarli, Massoud A Leesar, Kevin F Browne, Paul R Eisenberg, Roberto Bolli, A.Cecilia Casas, Victor Molina-Viamonte, Cesare Orlandi, Roger Blevins, Raymond J Gibbons, Robert M Califf, Christopher B Granger and for the AMISTAD Investigators
Table 2
Table 2
Treatment Detailslegend
| Anterior | Nonanterior | Total | ||||
|---|---|---|---|---|---|---|
| Adenosine | Placebo | Adenosine | Placebo | Adenosine | Placebo | |
| Time from study drug initiation to start of thrombolysis (min) | 0 (−8, 5) | 0 (−5, 5) | 0 (−5, 3) | 0 (−6, 6) | 0 (−6, 5) | 0 (−6, 5) |
| Duration of drug infusion (min) | 180 (180, 180) | 180 (180, 186) | 180 (175, 182) | 180 (180, 185) | 180 (180, 180) | 180 (180, 185) |
| Time from symptom onset to start of thrombolysis (min) | 195 (135, 295) | 165 (113, 215) | 206 (140, 275) | 175 (110, 230) | 200 (136, 285) | 172 (110, 228) |
| Time from symptom onset to hospital arrival (min) | 94 (44, 173) | 80 (43, 150) | 120 (74, 168) | 91 (51, 146) | 111 (60, 170) | 90 (47, 150) |
| Time from hospital arrival to start of thrombolysis (min) | 74 (50, 125) | 71 (53, 107) | 67 (46, 86) | 65 (43, 90) | 68 (47, 108) | 70 (43, 93) |
↵legend Data presented are median (25th, 75th percentiles).
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