Author + information
- Received September 13, 1999
- Revision received March 16, 2000
- Accepted April 19, 2000
- Published online September 1, 2000.
- Michael G Shlipak, MD, MPH∗,†,* (, )
- Alan S Go, MD†,‡,
- Paul D Frederick, MPH, MBA§,
- Judith Malmgren, PhD§,
- Hal V Barron, MD, FACC†∥,
- John G Canto, MD, MSPH, FACC¶,
- for the National Registry of Myocardial Infarction 2 Investigators
- ↵*Reprint requests and correspondence: Dr. Michael G. Shlipak, General Internal Medicine Section, VA Medical Center (111A1), San Francisco, California 94121
We sought to determine the importance of chest pain on presentation as a predictor of in-hospital treatment and mortality in myocardial infarction (MI) patients with left bundle-branch block (LBBB).
Left bundle-branch block patients have a high mortality after MI but are unlikely to receive reperfusion therapy despite evidence from clinical trials demonstrating the efficacy of thrombolytic therapy. Nearly half of MI patients with LBBB present without chest pain.
We studied the clinical features, treatment and in-hospital survival of 29,585 patients with LBBB enrolled in the National Registry of MI 2 (June 1994 through March 1998). Multivariate logistic regression was used to assess the independent effect of chest pain on reperfusion decisions and in-hospital mortality.
Left bundle-branch block patients with chest pain were greater than five-fold more likely to receive reperfusion therapy (13.6% vs. 2.6%) than LBBB patients without chest pain; they were also more likely to receive aspirin, beta-adrenergic blocking agents, heparin and nitrates (all p < 0.0001). Unadjusted in-hospital mortality was 18% in patients with chest pain and 27% in patients without chest pain. Adjusting for patient characteristics reduced the odds ratio associated with the absence of chest pain from 1.47 (95% confidence interval: 1.41 to 1.54) to 1.21 (95% confidence interval: 1.12 to 1.30). The remainder of the mortality difference was caused by the undertreatment of patients without chest pain, particularly the low utilization of aspirin and beta-blockers.
Left bundle-branch block patients with MI who present without chest pain are less likely to receive optimal therapy and are at increased risk of death. Prompt recognition and treatment of this high-risk subgroup should improve survival.
This paper was presented in part at the 72nd Annual Sessions of the American Heart Association, November 10, 1999, in Atlanta, Georgia.
- Received September 13, 1999.
- Revision received March 16, 2000.
- Accepted April 19, 2000.
- American College of Cardiology