Journal of the American College of Cardiology
Review article
Shifting the open-artery hypothesis downstream: the quest for optimal reperfusion
Matthew T Roe, E.Magnus Ohman, Arthur C.P Maas, Robert H Christenson, Kenneth W Mahaffey, Christopher B Granger, Robert A Harrington, Robert M Califf and Mitchell W Krucoff
Table 2
Table 2
Mortality by Degree of ST Segment Resolution After Fibrinolysis∗legend
| Trial | Time of ST Segment Analysis (min) | Follow-Up (days) | n | Resolution of ST Segment Elevation | p Value | ||
|---|---|---|---|---|---|---|---|
| Complete | Partial | None | |||||
| ISAM (49) | 180 | 35 | 1,516 | 2.8% | 4.3% | 9.2% | < 0.001 |
| INJECT (50) | 180 | 35 | 1,398 | 2.5% | 4.3% | 17.5% | < 0.001 |
| HIT-4 (51) | 180 | 35 | 998 | 2.8% | 6.0% | 14.3% | < 0.001 |
| TIMI-14 (52) | 90 | 30 | 444 | 1.0% | 4.2% | 5.9% | < 0.001 |
↵∗ Complete ST segment resolution was ≥70% from baseline; partial resolution was 31% to 69% from baseline; no resolution was ≤30% from baseline.
↵legend HIT = Hirudin for Improvement inThrombolysis; INJECT = International Joint Efficacy Comparison of Thrombolytics; ISAM = Intravenous Streptokinase inAcute Myocardial infarction; TIMI = Thrombolysis In Myocardial Infarction.
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