Author + information
- Received August 14, 2000
- Revision received January 26, 2001
- Accepted February 12, 2001
- Published online June 1, 2001.
- Romualdo Belardinelli, MD, FESC∗,* (, )
- Ivana Paolini, PhD†,
- Giovanni Cianci, MD‡,
- Roberto Piva, MD§,
- Demetrios Georgiou, MD, FACC∥ and
- Augusto Purcaro, MD¶
- ↵*Reprint requests and correspondence: Dr. Romualdo Belardinelli, Via Rismondo, 5-60100 Ancona, Italy.
Presented at the 71st Scientific Sessions of the American Heart Association, November 8–11, 1998, Dallas, Texas.
The goal of this study was to determine the effects of exercise training (ET) on functional capacity and quality of life (QOL) in patients who received percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting (CS), the effects on the restenosis rate and the outcome.
It is unknown whether ET induces beneficial effects after coronary angioplasty.
We studied 118 consecutive patients with coronary artery disease (mean age 57 ± 10 years) who underwent PTCA or CS on one (69%) or two (31%) native epicardial coronary arteries. Patients were randomized into two matched groups. Group T (n = 59) was exercised three times a week for six months at 60% of peak V̇O2. Group C (n = 59) was the control group.
Only trained patients had significant improvements in peak V̇O2(26%, p < 0.001) and quality of life (26.8%, p = 0.001 vs. C). The angiographic restenosis rate was unaffected by ET (T: 29%; C: 33%, P = NS) and was not significantly different after PTCA or CS. However, residual diameter stenosis was lower in trained patients (−29.7%, p = 0.045). In patients with angiographic restenosis, thallium uptake improved only in group T (19%; p < 0.001). During the follow-up (33 ± 7 months) trained patients had a significantly lower event rate than controls (11.9 vs. 32.2%, RR: 0.71, 95% confidence interval [CI]: 0.60 to 0.91, p = 0.008) and a lower rate of hospital readmission (18.6 vs. 46%, RR: 0.69, 95% CI: 0.55 to 0.93, p < 0.001).
Moderate ET improves functional capacity and QOL after PTCA or CS. During the follow-up, trained patients had fewer events and a lower hospital readmission rate than controls, despite an unchanged restenosis rate.
☆ Supported by the Azienda Ospedaliera G. M. Lancisi, Ancona, Italy.
- Received August 14, 2000.
- Revision received January 26, 2001.
- Accepted February 12, 2001.
- American College of Cardiology