|TIMI-IIIB||1995||1473||Patients 21–76 years of age presenting within 24 h of ischemic discomfort at rest consistent with unstable angina or non-Q-wave MI||Medical therapy (tPA vs. placebo) and early invasive or conservative strategy||6 weeks||16.2% combined primary endpoints||18.1% combined primary endpoints||NS||While no difference was found in combined primary endpoints (death, MI, positive ETT), the early invasive strategy was associated with shorter hospital stay and lower incidence of rehospitalization|
|VANQWISH||1998||920||Patients with an evolving MI||Invasive vs conservative||Avg 23 months||32.9% death and MI||30.3% death and MI||p = 0.35||Fewer patients treated conservatively had death plus MI or death at hospital discharge at 1 month and at 1 year. The invasive group had a higher CABG mortality rate (11.6% vs. 3.4%)|
|FRISC II||1999||2,457||Patient’s ischemic symptoms in previous 48 h accompanied by ECG changes or elevated markers||Early invasive therapy or noninvasive treatment strategy. Patients also received dalteparin or placebo for 3 months||6 months||9.4% death or MI||12.1% death or MI||p = 0.031||Invasive strategy was associated with 50% lower recurrent angina and hospital readmission rates|
↵legend CABG = coronary artery bypass graft; ECG = electrocardiography; ETT = exercise treadmill test; MI = myocardial infarction; NS = no significance; PCI = percutaneous coronary intervention.