Author + information
- Received October 11, 2001
- Revision received February 19, 2002
- Accepted February 20, 2002
- Published online May 15, 2002.
- Philipp Bonhoeffer, MD*,* (, )
- Younes Boudjemline, MD†,
- Shakeel A Qureshi, MD‡,
- Jerome Le Bidois, MD†,
- Laurence Iserin, MD†,
- Philippe Acar, MD†,
- Jacques Merckx, MD†,
- Jean Kachaner, MD† and
- Daniel Sidi, MD†
- ↵*Reprint requests and correspondence:
Dr. Philipp Bonhoeffer, Cardiothoracic Unit, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, United Kingdom.
Objectives We report our experience of percutaneous valve insertion in pulmonary position in humans.
Background Over the past 40 years, prosthetic conduits have been developed to surgically establish continuity between the right ventricle and the pulmonary artery. However, stenosis and insufficiency of the conduit due to valvular degeneration or panus ingrowth frequently occur, limiting patients’ lifespan. Percutaneous stenting of conduits has recently emerged as a technique for delaying surgical replacement, but it creates a pulmonary regurgitation when crossing the valve.
Methods Seven children and one adult with stenosis and/or insufficiency of the pulmonary graft underwent percutaneous implantation of a bovine jugular valve in pulmonary position.
Results Percutaneous pulmonary valve (PV) replacement was successful in all patients. No complications occurred in early follow-up. Angiography, hemodynamic studies and echocardiography after the procedure showed no significant regurgitation of the implanted valve. Implantation was effective in relieving the obstruction in five patients. All patients showed improvement in their clinical status at the latest follow-up (mean 10.1 months).
Conclusions Non-surgical insertion of the PV is possible without any major complications. This new technique may have an important role in the management of conduit obstructions and pulmonary regurgitation.
☆ The study was carried out in Necker Enfants Malades (Paris, France) and supported by the “Centre d’Etude des Cardiopathies Congénitales du Nourrissons” (Paris, France).
- Received October 11, 2001.
- Revision received February 19, 2002.
- Accepted February 20, 2002.
- American College of Cardiology Foundation