Author + information
- Received November 15, 1983
- Revision received January 3, 1984
- Accepted January 6, 1984
- Published online July 1, 1984.
- Allan S. Lew, MD, FRACP*,1,
- Tobi Neer, MT, (ASCP)1,
- Lois Rodriguez, RN, BSN1,
- Ivor L. Geft, MD, FRCP1,
- Prediman K. Shah, MD, FACC1 and
- William Ganz, MD, CSC, FACC1
- ↵*Address for reprints: Allan S. Lew, MD, Department of Cardiology, Room 5314, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, California 90048.
Neutralization of streptokinase by an unsuspected high titer of antiStreptokinase antibody prevented activation of the fibrinolytic system and induction of a lytic state in a 62 year old man with an acute inferior myocardial infarction. There was no decrease in serum fibrinogen, minimal decrease in serum plasminogen and only a small increase in serum fibrin degradation products after in- travenous administration of 1.5 million units of streptokinase. A high titer of antiStreptokinase antibody, sufficient to neutralize 1.5 million units of streptokinase, was demonstrated by semiquantitative counterelectro-phoresis. There was no clinical evidence of coronary artery reperfusion, and coronary angiography confirmed complete occlusion of the left circumflex artery.
- Received November 15, 1983.
- Revision received January 3, 1984.
- Accepted January 6, 1984.
- American College of Cardiology Foundation