Author + information
- Received February 21, 1984
- Revision received May 22, 1984
- Accepted June 12, 1984
- Published online December 1, 1984.
- Nagara Tamaki, MD*,1,
- Yoshiharu Yonekura, MD1,
- Takao Mukai, PhD1,
- Shusei Kodama, MD1,
- Kazunori Kadota, MD1,
- Hirofumi Kambara, MD1,
- Chuichi Kawai, MD, FACC1 and
- Kanji Torizuka, MD1
- ↵*Address for reprints: Nagara Tamaki, MD, Department of Radiology and Nuclear Medicine, Kyoto University School of Medicine, Sakyo-ku, Kyoto 606, Japan.
Stress thallium-201 myocardial distribution was quantitatively evaluated by emission transaxial tomography in 104 patients who underwent coronary arteriography. The initial uptake and percent washout of thallium were assessed by the circumferential profile curves of the three short-axis sections and one middle right anterior oblique long-axis section. This quantitative tomographic analysis showed abnormal distribution in all but two patients (98%) with coronary artery disease, whereas qualitative analysis showed abnormality in 76 of the patients (93%).
Quantitative analysis showed better sensitivity (91%) for detecting involved coronary vessels than qualitative analysis (80%, p < 0.01), especially in three vessel disease (82 versus 67%, p < 0.05). For localization of individual vessel involvement, quantitative analysis showed high sensitivity (right coronary artery: 96%, left anterior descending artery: 90% and left circumflex artery: 88%) as compared with qualitative analysis (88, 83 and 63%, respectively, p < 0.05), while similar specificity was observed (92% for quantitative and 93% for qualitative analyses). Furthermore, in the study of patients without infarction, myocardial segments supplied by coronary vessels with moderate stenosis (51 to 75%) revealed abnormality more often with quantitative (81%) than with qualitative (56%) analysis.
Thus, quantitative analysis of stress thallium emission tomography provides improved sensitivity for the detection of diseased coronary vessels in patients with three vessel disease and those with moderate stenosis. It is a valuable technique for the evaluation of coronary artery disease.
- Received February 21, 1984.
- Revision received May 22, 1984.
- Accepted June 12, 1984.
- American College of Cardiology Foundation