Net change in coronary angiogram and intravascular ultrasound parameters. The open columnsshow the medication (med) group and the solid columnsthe low density lipoprotein-apheresis (LDL-A) group. Net changes of minimal lumen diameter (MLD) (0.12 ± 0.43 mm in the LDL-A vs. −0.08 ± 0.45 mm in the medication group, p = 0.004) during one-year follow-up showed significant differences in both the LDL-A group and the medication group. The average net change of MLD was positive in the LDL-A group, whereas it was negative in the medication group (A). Net changes of plaque area (−0.69 ± 2.08 mm2in the LDL-A vs. 0.88 ± 1.75 mm2in the medication group, p = 0.008) were also significantly different between the LDL-A group and the medication group. The average net change of plaque area was negative in LDL-A subjects, while it was positive in medication subjects (B). No significant differences were seen in net change of lumen area (C, p = 0.13) and vessel area (D, p = 0.26) between the two groups.