Author + information
- Received July 2, 2002
- Revision received November 25, 2002
- Accepted January 9, 2003
- Published online May 21, 2003.
- Gary D Plotnick, MD, FACC*,* (, )
- Mary C Corretti, MD, FACC*,
- Robert A Vogel, MD, FACC*,
- Robert Hesslink Jr, ScD† and
- John A Wise, PhD†
- ↵*Reprint requests and correspondence:
Dr. Gary D. Plotnick, Cardiology Division, University of Maryland Medical Center, 22 South Greene Street, Baltimore, Maryland 21201, USA.
Objectives Our objective was to determine if long-term daily administration of phytonutrient supplements can prevent the immediate adverse impact of a high-fat meal and increase the production of nitric oxide.
Background Ingestion of a high-fat meal impairs flow-mediated vasodilation of the brachial artery for at least 4 h; however, co-ingestion of vitamin antioxidants or a green salad has been shown to prevent this effect.
Methods Flow-mediated brachial artery reactivity test (BART) both before and 3 h after a 900 calorie 50 g fat meal was evaluated in 38 healthy volunteers (age 36.4 ± 10.1 years). Subjects were randomized to four weeks of daily supplementation with a powdered fruit vegetable juice concentrate (Juice Plus [JP]) along with a complex supplement providing nutritional antioxidants and various herbal extracts (Vineyard [V]), JP alone, or a matching placebo. At three and four weeks, BART was repeated both before and after the high-fat meal. Serum nitrate/nitrite concentrations were measured at baseline and at four weeks.
Results Four weeks of the JP-V combination blunted the detrimental effect of the high-fat meal (−47.5 ± 23.4% at baseline vs. −1.7 ± 9.7% at four weeks [p < 0.05]). Four weeks of JP alone had a similar beneficial effect (−45.1 ± 19.7% at baseline vs. −16.6 ± 10.3% at four weeks [p < 0.05]), whereas there was no substantial effect of the placebo. In the subjects treated with supplements, concentrations of serum nitrate/nitrite increased from 78 ± 39 to 114 ± 62 μm/l (p < 0.02).
Conclusions Daily ingestion of modest amounts of a fruit/vegetable juice concentrate with or without adjunctive phytonutrient supplementation can reduce the immediate adverse impact of high-fat meals on flow-mediated vasoactivity and increase nitrate/nitrite blood concentration.
☆ Dr. Plotnick was supported by a grant from Natural Alternatives International.
- Received July 2, 2002.
- Revision received November 25, 2002.
- Accepted January 9, 2003.
- American College of Cardiology Foundation