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I read with great interest the study by Mahon et al. (1)demonstrating abnormal myocardial pathology in apparently asymptomatic relatives of patients with idiopathic dilated cardiomyopathy (DCM). This finding, of course, has great clinical import. The investigators state that their study “provides, for the first time, to the best of our knowledge, direct pathologic confirmation that relatives with LVE (left ventricular enlargement) have myocardial disease …”. Several years ago, histopathologic changes were reported in a smaller number of asymptomatic first-degree relatives of patients with DCM (2). That study claimed, more correctly, to have shown “for the first time that the myocardium in such relatives demonstrates abnormal cellularity”. The study was published in a nonobscure, English-language journal and, most suprisingly, Dr. Mahon was one of the co-authors!
- American College of Cardiology Foundation