Table 5

Journal of the American College of Cardiology

Volume 41, Issue 8, April 2003 DOI: 10.1016/S0735-1097(03)00121-9

Effects of the oral endothelin-receptorantagonist bosentan on echocardiographicand doppler measures in patients with pulmonary arterial hypertension

Nazzareno Galiè, Alan L. Hinderliter, Adam Torbicki, Thierry Fourme, Gerald Simonneau, Tomas Pulido, Nilda Espinola-Zavaleta, Guido Rocchi, Alessandra Manes, Robert Frantz, Marcin Kurzyna, Sherif F. Nagueh, Robyn Barst, Richard Channick, Karl Dujardin, Andrew Kronenberg, Isabelle Leconte, Maurizio Rainisio and Lewis Rubin

Table 5

Changes From Baseline in Doppler Variables by Treatment Group and Treatment Effect

Variables	Placebo		Bosentan Groups Combined		Treatment Effect		125 mg of Bosentan		Treatment Effect		250 mg of Bosentan		Treatment Effect
Variables	n	C ± SEM*	n	C ± SEM*	Mean	p†	n	C ± SEM*	Mean	p†	n	C ± SEM*	Mean	p†
RV acceleration time, ms	27	−2.41 ± 3.40	50	3.46 ± 2.63	5.87	0.169	25	−0.56 ± 3.21	1.85	0.59	25	7.48 ± 4.08	9.89	0.073
RV ejection time, ms	27	−3.81 ± 5.72	50	18.34 ± 4.03	22.15	0.007	25	14.8 ± 5.48	17.89	0.052	25	22.6 ± 5.90	26.41	0.007
Doppler RV index	26	−0.01 ± 0.03	45	−0.08 ± 0.02	−0.06	0.034	22	−0.06 ± 0.02	−0.05	0.075	23	−0.09 ± 0.03	−0.07	0.070
Maximal TV regurgitant velocity, cm/s	25	6.40 ± 6.45	46	−4.50 ± 5.50	−10.90	0.280	23	−8.48 ± 8.35	−14.88	0.155	23	−0.52 ± 7.27	−6.92	0.681
LV stroke volume, ml	26	0.06 ± 2.04	55	7.43 ± 1.45	7.37	0.007	28	5.94 ± 2.14	5.88	0.071	55	8.97 ± 1.96	8.91	0.005
Heart rate, beats/min	27	−2.11 ± 2.82	55	−4.42 ± 1.45	−2.31	0.118	28	−2.32 ± 1.46	−0.21	0.274	27	−6.59 ± 2.49	−4.48	0.109
Cardiac index, l/min/m²	26	−0.18 ± 0.11	55	0.19 ± 0.07	0.37	0.007	28	0.18 ± 0.09	0.36	0.020	27	0.20 ± 0.12	0.38	0.021
Doppler MV peak E velocity, cm/s	24	−2.54 ± 2.82	53	7.91 ± 2.40	10.45	0.003	27	3.74 ± 3.49	6.28	0.062	26	12.23 ± 3.13	14.77	0.001
Doppler MV E/A ratio	24	−0.03 ± 0.05	53	0.15 ± 0.04	0.18	0.004	27	0.11 ± 0.06	0.15	0.024	26	0.18 ± 0.05	0.21	0.006
Doppler MV time-velocity integral, cm	24	−0.27 ± 0.48	53	2.07 ± 0.40	2.34	0.001	27	1.15 ± 0.52	1.42	0.054	26	3.02 ± 0.56	3.29	0.000

MV = mitral valve; LV = left ventricle; RV = right ventricle; TV = tricuspid valve.

↵* C ± SEM denotes mean change ± standard error of the mean.
↵† p values are for the comparison with the placebo group.

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Effects of the oral endothelin-receptorantagonist bosentan on echocardiographicand doppler measures in patients with pulmonary arterial hypertension

Table 5

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